{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:27:47Z","timestamp":1778776067224,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to analyze the long\u2010term outcomes of transplants utilizing ITx donors &lt;1\u00a0year and to compare these results with older donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2007 and December 2019, the primary ITx donors in the Children's Hospital of Pittsburgh of UPMC were retrospectively reviewed. Short\u2010 and long\u2010term outcomes of recipients receiving a deceased donor organ from donors &lt;1\u00a0year were compared with those found in all other recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, there were 89 primary ITx donors, using 30 donors (33.7%) aged &lt;1\u00a0year. The mean age of their recipients was 1.6\u00a0\u00b1\u00a00.7 (0.7\u20133.2) years. The 30\u00a0graft types were isolated intestine (<jats:italic>n<\/jats:italic>\u00a0=\u00a03, 10.0%), liver bowel (<jats:italic>n<\/jats:italic>\u00a0=\u00a020, 66.7%), and multivisceral (<jats:italic>n<\/jats:italic>\u00a0=\u00a07, 23.3%). Technical complications occurred in 12 (40.0%) recipients. Candidates transplanted with intestine allografts from donors &lt;1\u00a0year of age had shorter wait times (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), more liver\u2010inclusive grafts (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and less donor\u2010specific antibodies (DSA) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.014). During follow\u2010up, the recipients had less graft loss (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.018), and more remained alive with graft in place (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.011). Among children transplanted with such donors, 3\u2010year and graft survival rates were 86.7% and 82.9% compared to 62.8% and 49.9% in the cohort of donors &gt;1\u00a0year (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.032 and .011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Donor age &lt;1\u00a0year was associated with improved graft survival. Optimal utilization of this population for toddler candidates would increase intestine availability, reduce time to transplantation, and potentially improve long\u2010term outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14257","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T15:29:37Z","timestamp":1645630177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term outcomes of intestinal transplantation from donors aged under 1\u00a0year"],"prefix":"10.1111","volume":"26","author":[{"given":"Yu\u2010Tang","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Division of Pediatric Transplantation Department of Surgery Hillman Center for Pediatric Transplantation Children\u2019s Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-7234","authenticated-orcid":false,"given":"Kyle","family":"Soltys","sequence":"additional","affiliation":[{"name":"Division of Pediatric Transplantation Department of Surgery Hillman Center for Pediatric Transplantation Children\u2019s Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-0440","authenticated-orcid":false,"given":"Ajai","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Pediatric Transplantation Department of Surgery Hillman Center for Pediatric Transplantation Children\u2019s Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey J.","family":"Bond","sequence":"additional","affiliation":[{"name":"Division of Pediatric Transplantation Department of Surgery Hillman Center for Pediatric Transplantation Children\u2019s Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Ganoza","sequence":"additional","affiliation":[{"name":"Division of Pediatric Transplantation Department of Surgery Hillman Center for Pediatric Transplantation Children\u2019s Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Pediatrics Children\u2019s Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8525-6694","authenticated-orcid":false,"given":"Rakesh","family":"Sindhi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Transplantation Department of Surgery Hillman Center for Pediatric Transplantation Children\u2019s Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-8632","authenticated-orcid":false,"given":"George V.","family":"Mazariegos","sequence":"additional","affiliation":[{"name":"Division of Pediatric Transplantation Department of Surgery Hillman Center for Pediatric Transplantation Children\u2019s Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"UpToDate Inc FA Khan G Selvaggi TW Post Overview of intestinal and multivisceral transplantation"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2018.07.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2017.07.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2010.03044.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0041\u20101345(96)00406\u2010x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.04.021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31820000a1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816dd236"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000584"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-07284-5_22"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2003.50033"},{"key":"e_1_2_10_13_1","unstructured":"Organ Procurement and Transplantation Network.National data. 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