{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:31:22Z","timestamp":1768908682809,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to characterize features present at the time of diagnosis and describe outcomes in patients with post\u2010transplant lymphoproliferative disorder (PTLD) following pediatric solid organ transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of solid organ transplant patients who developed pathologically confirmed PTLD at our center from 2006 to 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 594 patients included in this study, 41(6.9%) were diagnosed with PTLD. Median age at transplant was 5.6(IQR 1.7\u201316.1) years. Proportion of PTLD cases by organ transplanted and median time (IQR) to disease onset were: heart 11\/144(7.6%) at 13.6(8.5\u201355.6) months, lung 7\/52(13.5%) at 9.1(4.9\u201335) months, kidney 8\/255(3.1%) at 39.5(13.9\u201357.1) months, liver 12\/125(9.6%) at 7.7(5.5\u201322) months, intestine 0\/4(0%), and multi\u2010visceral 3\/14(21.4%) at 5.4(5.4\u20135.6) months. No significant correlation was seen between recipient EBV status at transplant and timing of development of PTLD. There were six early lesions, 15 polymorphic, 19\u00a0monomorphic, and one uncharacterizable PTLD. Following immunosuppression reduction, 30 patients received rituximab, and 14 required chemotherapy. At median 25(IQR 12\u201353) months follow\u2010up from the onset of PTLD, eight patients died secondary to transplant related complications, three are alive with active disease, and 30\u00a0have no evidence of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PTLD is a significant complication following pediatric solid organ transplantation. EBV levels in conjunction with symptomatic presentation following transplant may assist in detection of PTLD. Most patients can achieve long\u2010term disease\u2010free survival through immunosuppression reduction, anti\u2010CD20 treatment, and chemotherapy in refractory cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14268","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T07:05:01Z","timestamp":1647673501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Presentation and outcomes of post\u2010transplant lymphoproliferative disorder at a single institution pediatric transplant center"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-161X","authenticated-orcid":false,"given":"Gabriel","family":"Ramos\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Department of Surgery Boston Children\u2019s Hospital  Boston Massachusetts 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