{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:16Z","timestamp":1753879156810,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Brugada syndrome is an inherited channelopathy characterized by arrhythmia and an increased risk of sudden cardiac death (SCD). Implantation of a defibrillator for primary or secondary prevention is the only effective strategy to decrease the risk of SCD in Brugada syndrome. We present a case in which a cardiac donor had a pathogenic variant for Brugada syndrome, discovered on genetic testing after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A young child with dilated cardiomyopathy underwent orthotopic heart transplantation from a donor with in\u2010hospital cardiac arrest in the context of fever and a normal ECG. Approximately 1\u00a0month after transplant, the donor's post mortem genetic testing revealed a pathogenic loss\u2010of\u2010function <jats:italic>SCN5A<\/jats:italic> variant associated with Brugada syndrome, which was confirmed on genetic testing on a post\u2010transplant endomyocardial biopsy from the recipient. The recipient's post\u2010transplant electrocardiographic monitoring revealed persistent right bundle branch block and progressive, asymptomatic sinus node dysfunction. The recipient was managed with precautionary measures including aggressive fever management, avoidance of drugs that increase arrhythmia risk in Brugada syndrome, and increased frequency of arrhythmia surveillance. The recipient remains asymptomatic at over 3\u00a0years post\u2010transplant with preserved graft function and no documented ventricular arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We describe the clinical course of \u201cacquired\u201d Brugada syndrome in a cardiac allograft recipient, which has not been previously reported. The time\u2010sensitive nature of donor organ selection, especially in critically ill recipients, combined with the growing use of molecular autopsies in patients with unexplained etiologies for death may increasingly result in important donor genetic information being made available after transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14276","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T13:38:48Z","timestamp":1648388328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cAcquired\u201d Brugada syndrome in a cardiac allograft"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-6848","authenticated-orcid":false,"given":"Alyssa","family":"Power","sequence":"first","affiliation":[{"name":"Department of Pediatrics UT Southwestern Medical Center and Children\u2019s Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ine","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Zahavich","sequence":"additional","affiliation":[{"name":"Department of Genetic Counseling Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien A.","family":"L\u00e9vesque","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Sherbrooke Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-2215","authenticated-orcid":false,"given":"Emilie","family":"Jean\u2010St\u2010Michel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-7222","authenticated-orcid":false,"given":"Anne I.","family":"Dipchand","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-6554","authenticated-orcid":false,"given":"Aamir","family":"Jeewa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hospital for Sick Children, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.06.037"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.238469"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy412"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.06.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12402"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2013.09.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.05.056"},{"issue":"11","key":"e_1_2_10_9_1","first-page":"1864","article-title":"Brugada syndrome in the young: an assessment of risk factors predicting future events","volume":"19","author":"Gonzalez Corcia MC","year":"2017","journal-title":"EP Europace"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.04.045"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951121003413"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.664219"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.01.1345"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13764"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-018-0045-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.08.009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2020.10.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2010.12.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.04.024"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.03.177"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T12:58:23Z","timestamp":1725627503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,27]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/petr.14276"],"URL":"https:\/\/doi.org\/10.1111\/petr.14276","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2022,3,27]]},"assertion":[{"value":"2022-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14276"}}