{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:49:19Z","timestamp":1791499759990,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemoglobin (Hb) Hammersmith is a rare form of unstable \u03b2\u2010chain hemoglobinopathy causing hemolytic anemia. This rare event led to a more serious transfusion\u2010dependent phenotype in a patient. It was successfully cured by haploidentical hematopoietic stem cell transplantation (HSCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A 9\u2010year\u2010old mainland Chinese male with a history of neonatal unconjugated hyperbilirubinemia was diagnosed to have hemoglobin (Hb) Hammersmith. He required regular blood transfusion but was unable to be transfused to desired parameters for 8\u00a0years prior to transplant due to social and geographical reasons. He subsequently developed marrow hyperplasia and progressive splenomegaly (down to umbilicus level), suggestive of extramedullary hematopoiesis. Eventually, the family came to Hong Kong and complied to a more intensive transfusion regimen and preconditioning chemotherapy 3\u00a0months prior to transplant. He underwent haploidentical HSCT using paternal TCR\u03b1\u03b2\/CD45RA\u2010depleted graft but suffered from graft rejection, despite splenic irradiation for massive splenomegaly. It was successfully salvaged with second HSCT with unmanipulated graft from the same donor with additional serotherapy and donor lymphocyte infusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Allogenic haploidentical HSCT for hemoglobin Hammersmith is feasible but adequate immunosuppression during conditioning is crucial. Precise adoptive cell therapy can promote durable engraftment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14278","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T09:24:19Z","timestamp":1649496259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful haploidentical hematopoietic stem cell transplantation (HSCT) and durable engraftment by repeated donor lymphocyte infusions for a Chinese patient with transfusion\u2010dependent hemoglobin (Hb) Hammersmith and massive splenomegaly"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4178-2777","authenticated-orcid":false,"given":"Wilson Y. K.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Hong Kong Children\u2019s Hospital Hong Kong Special Administrative Region  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson C. N.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Pathology Hong Kong Children\u2019s Hospital Hong Kong Special Administrative Region  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C. C.","family":"So","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Pathology Hong Kong Children\u2019s Hospital Hong Kong Special Administrative Region  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela P. 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