{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:38:25Z","timestamp":1790743105132,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ex vivo split liver transplantation in pediatric recipients has shown inferior results compared with whole grafts. One factor among others contributing to split grafts being considered as marginal is the prolonged static cold storage time related to ex vivo liver splitting. End ischemic hypothermic oxygenated perfusion is a validated strategy to improve outcomes of marginal whole grafts and may thus also benefit split liver grafts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We present the first case of full left\/full right split procedure performed during hypothermic oxygenated perfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present a standardized surgical two\u2010step approach where parenchymal transection was performed during end ischemic hypothermic oxygenated perfusion via the portal vein to shorten static cold storage duration. Both split grafts were successfully transplanted in a 4\u2010year\u2010old pediatric and a 38\u2010year\u2010old adult recipient. Despite high\u2010risk procedure (retransplantation), extended donor criteria including a prolonged cardiac arrest and high donor risk index (2,25), both grafts showed early recovery of hepatic function and low serum transaminase release. At 6\u00a0months, both recipients were alive with a normal liver biology and a functioning graft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although challenging, full left\/full right liver split procedure during end ischemic hypothermic oxygenated perfusion can be successfully performed and is a promising strategy to improve post\u2010transplant outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14284","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T05:59:43Z","timestamp":1650347983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Full left\/full right liver graft ex situ split during hypothermic oxygenated perfusion"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-4144","authenticated-orcid":false,"given":"Guillaume","family":"Rossignol","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery and Liver Transplantation Femme Mere Enfant University Hospital  Hospices Civils de Lyon France"},{"name":"Department of General Surgery and Liver Transplantation Croix\u2010Rousse University Hospital  Hospices Civils de Lyon France"},{"name":"The Lyon Cancer Research Centre INSERM U1052 UMR 5286  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8849-5495","authenticated-orcid":false,"given":"Xavier","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Liver Transplantation Croix\u2010Rousse University Hospital  Hospices Civils de Lyon France"},{"name":"The Lyon Cancer Research Centre INSERM U1052 UMR 5286  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9695-0902","authenticated-orcid":false,"given":"Kayvan","family":"Mohkam","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Liver Transplantation Femme Mere Enfant University Hospital  Hospices Civils de Lyon France"},{"name":"Department of General Surgery and Liver Transplantation Croix\u2010Rousse University Hospital  Hospices Civils de Lyon France"},{"name":"The Lyon Cancer Research Centre INSERM U1052 UMR 5286  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Liver Transplantation Femme Mere Enfant University Hospital  Hospices Civils de Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-4599","authenticated-orcid":false,"given":"Micka\u00ebl","family":"Lesurtel","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Liver Transplantation Croix\u2010Rousse University Hospital  Hospices Civils de Lyon France"},{"name":"The Lyon Cancer Research Centre INSERM U1052 UMR 5286  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5701-3588","authenticated-orcid":false,"given":"Jean\u2010Yves","family":"Mabrut","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Liver Transplantation Croix\u2010Rousse University Hospital  Hospices Civils de Lyon France"},{"name":"The Lyon Cancer Research Centre INSERM U1052 UMR 5286  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13147"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32223"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25340"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13824"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2031532"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004268"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005110"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32343"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003775"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001116"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25843"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200011000-00007"},{"key":"e_1_2_9_14_1","unstructured":"Hospices Civils de Lyon.End\u2010ischemic Hypothermic Oxygenated Perfusion for Extended Criteria Donors in Liver Transplantation \u2010 A Multicenter Randomized Controlled Trial [Internet]. clinicaltrials.gov; Report No.: NCT03929523. 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