{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:18:13Z","timestamp":1771031893935,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Guidance and data on ventricular assist device (VAD) support for children with chemotherapy\u2010induced cardiomyopathy, particularly within the first 2\u00a0years after chemotherapy, are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center retrospective case series, reviewing medical records of children &lt;18\u00a0years of age with chemotherapy\u2010induced cardiomyopathy and advanced heart failure (HF) who received durable VAD support.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six patients met inclusion criteria\u20145 HeartWare\u2122 HVAD, 1 Berlin Heart EXCOR<jats:sup>\u00ae<\/jats:sup>. Median age at cancer diagnosis was 6\u00a0years (IQR 4.5\u201310\u00a0years). Median dose of anthracycline received was 540\u00a0mg\/m<jats:sup>2<\/jats:sup> (IQR 450\u2013630\u00a0mg\/m<jats:sup>2<\/jats:sup>). All patients developed HF within 1\u00a0year after initiation of cancer treatment (median 8\u00a0months, IQR 6\u201311.5\u00a0months) and were initiated on durable VAD support at a median of 8\u00a0months after completion of cancer treatment (IQR 3.3\u201343.5\u00a0months). Four patients had significant right ventricular dysfunction needing oral pulmonary vasodilator therapy, one patient had a major bleeding complication, and two patients had thromboembolic strokes while on VAD support. Median duration of VAD support was 7.5\u00a0months (IQR 3\u201311.3\u00a0months). Two patients underwent VAD explant due to recovery of LV function, one died due to cancer progression, and three underwent heart transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Durable VAD support should be considered as a therapeutic option for children who have advanced HF due to chemotherapy\u2010induced cardiomyopathy, even within 2\u00a0years of completing cancer treatment. A multi\u2010disciplinary approach is essential for appropriate patient selection prior to implant and to ensure comprehensive care throughout the duration of VAD support.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14286","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T04:07:15Z","timestamp":1651032435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ventricular assist device support for children with chemotherapy\u2010induced cardiomyopathy and advanced heart failure: Perspectives gained from a single\u2010center experience"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-2655","authenticated-orcid":false,"given":"Kriti","family":"Puri","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Cardiology Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"},{"name":"Department of Pediatrics Division of Critical Care Medicine Baylor College of Medicine Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-7257","authenticated-orcid":false,"given":"Susan W.","family":"Denfield","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iki","family":"Adachi","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery and Pediatrics Baylor College of Medicine Mechanical Circulatory Support Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack F.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-6252","authenticated-orcid":false,"given":"Joseph A.","family":"Spinner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-1711","authenticated-orcid":false,"given":"Swati","family":"Choudhry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julienne","family":"Brackett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Santucci","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Palliative Care Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nino C.","family":"Rainusso","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari P.","family":"Tunuguntla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology Baylor College of Medicine Texas Children\u2019s Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2019.07.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303633"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/942090"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00123"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz031"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001292"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13840"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2016.04.009"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-2272"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12923"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12398"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/amajethics.2019.380"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182a0d242"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.14503\/THIJ\u201015\u20105628"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.013"},{"key":"e_1_2_11_17_1","unstructured":"Interagency Registry for Mechanically Assisted Circulatory Support.Manual of operations and procedures version 4.0.http:\/\/www.uab.edu\/medicine\/intermacs\/images\/protocol_4.0\/protocol_4.0_MoP\/INTERMACS_MOP_Protocol_4_0_V1_0__06\u20103\u20102014.pdf. 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