{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:17:33Z","timestamp":1790371053404,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010transplant lymphoproliferative disorder (PTLD) are the most common de novo malignancies after liver transplantation (LT) in children. The aim of our study was to assess the role of pre\u2010LT EBV status and post\u2010LT EBV viral load as risk factors for developing PTLD in a cohort of pediatric LT recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of all children who underwent LT between January 2002 and December 2019 were collected. Two cohorts were built <jats:italic>EBV pre<\/jats:italic>\u2010<jats:italic>LT primary infected cohort<\/jats:italic> and <jats:italic>EBV post<\/jats:italic>\u2010<jats:italic>LT primary infected cohort<\/jats:italic>. Moreover, using the maximal EBV viral load, a ROC curve was constructed to find a cutoff point for the diagnosis of PTLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 251 patients included in the study, fifteen PTLD episodes in 14 LT recipients were detected (2 plasmacytic hyperplasia, 10 polymorphic PTLD, 2\u00a0monomorphic PTLD, and 1 Classical\u2010Hodgkin's lymphoma). Patients of the <jats:italic>EBV post<\/jats:italic>\u2010<jats:italic>LT primary infected<\/jats:italic> cohort were 17.1 times more likely to develop a PTLD than patients of the <jats:italic>EBV pre<\/jats:italic>\u2010<jats:italic>LT primary infected cohor<\/jats:italic>t (2.2\u2013133.5). The EBV viral load value to predict PTLD was set at 211\u00a0000 UI\/mL (93.3% sensitivity and 77.1% specificity; AUC 93.8%; IC 0.89\u20130.98). In <jats:italic>EBV post<\/jats:italic>\u2010<jats:italic>LT primary infected cohort<\/jats:italic>, patients with a viral load above 211\u00a0000 were 30 times more likely to develop PTLD than patients with a viral load below this value (OR 29.8; 3.7\u2013241.1; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of pretransplant EBV serological status with EBV post\u2010transplant viral load could be a powerful tool to stratify the risk of PTLD in pediatric LT patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14292","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T05:08:52Z","timestamp":1650863332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Epstein\u2013Barr virus\u2010associated risk factors for post\u2010transplant lymphoproliferative disease in pediatric liver transplant recipients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6456-9031","authenticated-orcid":false,"given":"Jesus","family":"Quintero Bernabeu","sequence":"first","affiliation":[{"name":"Pediatric Hepatology and Liver Transplant Unit Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-6374","authenticated-orcid":false,"given":"Javier","family":"Juamperez","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology and Liver Transplant Unit Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1687-6448","authenticated-orcid":false,"given":"Maria","family":"Mercadal\u2010Hally","sequence":"additional","affiliation":[{"name":"Pediatric Hepatology and Liver Transplant Unit Vall d'Hebron University Hospital  Barcelona 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Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-1341","authenticated-orcid":false,"given":"Juliana","family":"Esperalba","sequence":"additional","affiliation":[{"name":"Microbiology Department Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0093-9360","authenticated-orcid":false,"given":"Alexandra","family":"Navarro Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Histology Department Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garrido Pontnou","sequence":"additional","affiliation":[{"name":"Histology Department Vall d'Hebron University Hospital  Barcelona 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