{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:00:06Z","timestamp":1790200806297,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vaccine preventable illnesses are important sources of morbidity, mortality, and increased healthcare costs in pediatric LT recipients. Our aim was to measure the seroprevalence of antibodies to measles and VZV in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective chart review of 44 patients who received LT before age 18 at UCLA Mattel Children's Hospital from January 2008 to December 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age at transplantation was 2.5\u2009years (IQR 1.2\u20137.7). Post\u2010transplant measles antibodies were present in 17 of 37 patients (46%); risk factors for seronegativity included younger age at transplant (<jats:italic>p<\/jats:italic>\u00a0=\u2009.02) and greater time from transplant to testing (<jats:italic>p<\/jats:italic>\u00a0=\u2009.04). Post\u2010transplant VZV antibodies were present in 17 of 39 patients (44%); risk factors for seronegativity included greater time from transplant to testing (<jats:italic>p<\/jats:italic>\u00a0=\u2009.04). 6 of 16 patients (38%) who tested positive for pre\u2010transplant VZV antibodies tested negative after transplantation. Fourteen of 20 patients (70%) with at least 1 documented dose of the MMR vaccine tested positive for post\u2010transplant measles antibodies. Ten of 20 of patients (50%) with at least 1 documented dose of the VZV vaccine tested positive for post\u2010transplant VZV antibodies. We also describe 10 patients who received post\u2010transplant measles and VZV vaccines without documented complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that pediatric LT patients are at greater risk of contracting measles and VZV despite vaccination status, and that prevalence of measles and VZV antibodies decreases as time from transplantation increases. This should weigh into the institutional risk\u2013benefit assessment when deciding whether or not to administer LAVs to these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14322","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T06:15:36Z","timestamp":1652854536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low post\u2010transplant measles and varicella titers among pediatric liver transplant recipients: A 10\u2010year single\u2010center study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-1179","authenticated-orcid":false,"given":"Andrew Y. J.","family":"Liman","sequence":"first","affiliation":[{"name":"Department of Pediatrics Mattel Children's Hospital at UCLA Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Wozniak","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Mattel Children's Hospital at UCLA Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-7403","authenticated-orcid":false,"given":"Annabelle","family":"de St Maurice","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases Mattel Children's Hospital at UCLA Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Dunkel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Mattel Children's Hospital at UCLA Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emy M.","family":"Wanlass","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Mattel Children's Hospital at UCLA Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0956-3147","authenticated-orcid":false,"given":"Robert S.","family":"Venick","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Mattel Children's Hospital at UCLA Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue V.","family":"McDiarmid","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Mattel Children's Hospital at UCLA Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0507-4"},{"key":"e_1_2_11_3_1","unstructured":"Centers for Disease Control and Prevention.Measles Cases and Outbreaks 2021:210\u2010211.https:\/\/www.cdc.gov\/measles\/cases\u2010outbreaks.html. Accessed December 7 2021."},{"key":"e_1_2_11_4_1","volume-title":"Epidemiology and Prevention of Vaccine\u2010Preventable Diseases","author":"Centers for Disease Control and Prevention","year":"2015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.07.030"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200308000-00018"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04273.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15101"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.01.075"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.09.076"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.11.052"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01210.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13937"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00403.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200208270-00020"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81545-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002866"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13571"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13804"},{"issue":"90","key":"e_1_2_11_20_1","first-page":"1","article-title":"Infectious Disease Prevalence in Los Angeles County\u2013A Comparison to National Estimates, 1999\u20132004","author":"Kruszon\u2010Moran D","year":"2012","journal-title":"NCHS Data Brief"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13490"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00313.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-047092"},{"issue":"6","key":"e_1_2_11_24_1","first-page":"153","article-title":"Measles outbreak \u2014 California, December 2014\u2013February 2015","volume":"64","author":"Zipprich J","year":"2015","journal-title":"CDC Morbid Mortal Weekly Rep"},{"key":"e_1_2_11_25_1","unstructured":"Centers for Disease Control and Prevention.Recommended Child and Adolescent Immunization Schedule for ages 18\u2009years or younger United States 2021.https:\/\/www.cdc.gov\/vaccines\/schedules\/hcp\/imz\/child\u2010adolescent.html. Accessed December 11 2021."},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit684"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12765"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24104"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00596.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200011150-00023"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.1123"},{"key":"e_1_2_11_32_1","unstructured":"Centers for Disease Control and Prevention.General Best Practice Guidelines for Immunization: Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP) 2021.https:\/\/www.cdc.gov\/vaccines\/hcp\/acip\u2010recs\/general\u2010recs\/immunocompetence.html. Accessed December 7 2021."}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T12:58:44Z","timestamp":1725627524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,17]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/petr.14322"],"URL":"https:\/\/doi.org\/10.1111\/petr.14322","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,17]]},"assertion":[{"value":"2021-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14322"}}