{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:32:34Z","timestamp":1753878754297,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The anti\u2010CD20 rituximab is often used in the treatment of children with steroid\u2010resistant nephrotic syndrome or EBV\u2010induced post\u2010transplant lymphoproliferative disorder. This single\u2010center series reports the use of rituximab as induction therapy in pediatric kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four children who received rituximab as induction therapy for kidney transplantation since 2016 were retrospectively analyzed. Clinical and laboratory data were extracted from medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients (2 boys and 2 girls) were aged from 6.1 to 11.9\u2009years and were treated with rituximab on the day of the transplantation procedure; all the transplants came from deceased donors. In all patients, rituximab was used because of positive EBV viral loads before kidney transplantation. Viral loads remained undetectable for the first 6\u2009months after the transplantation procedure and remained below the 4.5 log threshold thereafter. After a median follow\u2010up of 2.3\u2009years, none of the patients displayed rejection or de novo donor\u2010specific antibodies; the glomerular filtration rate remained above 70\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>. No post\u2010transplant lymphoproliferative disorder was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that rituximab can be used as induction therapy to prevent EBV replication and its complications in case of positive viral load prior to kidney transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14329","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T04:14:16Z","timestamp":1654229656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rituximab as induction therapy in pediatric kidney transplantation: A single\u2010center experience in four patients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1342-3534","authenticated-orcid":false,"given":"Josselin","family":"Bernard","sequence":"first","affiliation":[{"name":"Pediatric Department University Hospital of Nantes  Nantes France"},{"name":"Pediatric Nephrology, Rheumatology and Dermatology Unit, Reference Center for Rare Renal Diseases H\u00f4pital Femme M\u00e8re Enfant, Rare Disease Networks ORKID and ERK\u2010Net, Hospices Civils de Lyon  Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Laure","family":"Sellier\u2010Leclerc","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Rheumatology and Dermatology Unit, Reference Center for Rare Renal Diseases H\u00f4pital Femme M\u00e8re Enfant, Rare Disease Networks ORKID and ERK\u2010Net, Hospices Civils de Lyon  Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Dem\u00e8de","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department H\u00f4pital Femme M\u00e8re Enfant, Hospices Civils de Lyon  Bron 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H\u00f4pital Femme M\u00e8re Enfant, Hospices Civils de Lyon  Bron France"},{"name":"Pharmacy Department Groupement Hospitalier Est, Hospices Civils de Lyon  Bron France"},{"name":"Lyon Est Medical School Lyon 1 University  Lyon 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