{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:32:37Z","timestamp":1753878757198,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Urinary CXCL10\/Cr is a promising diagnostic tool for early detection of TCMR in pediatric transplant recipients, and most studies focus on its utility in the context of localized allograft inflammation thus far. Other sources of inflammation that may be detected by CXCL10 are less clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present a case review of a patient with BL, who was enrolled in a prospective trial of urinary CXCL10 monitoring. To evaluate the potential confounding, we tested for association of CXCL10\/Cr and EBV viral load in a prospective cohort of pediatric transplant recipients with serial testing for urinary CXCL10\/Cr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This report describes a 15\u2010year\u2010old boy, 3.5\u2009years post\u2010transplant with chronic EBV viremia, stable kidney function and no history of rejection. Urinary CXCL10\/Cr level increased acutely to 79.43\u2009ng\/mmol, 0.8\u2009months prior to onset of BL, identified by a surge in EBV viral load. In a national cohort of 97 pediatric kidney transplant recipients, there was no association between urinary CXCL10\/Cr with EBV viral loads when comparing periods of pre\u2010viremia (5.8\u00a0\u00b1\u20099.2\u00a0ng\/mmol) to active viremia (4.0\u00a0\u00b1\u20095.3\u00a0ng\/mmol) and periods of active viremia (7.1\u00a0\u00b1\u20098.9\u00a0ng\/mmol) to post\u2010viremia (4.4\u00a0\u00b1\u20099.8\u00a0ng\/mmol).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute rise in urinary CXCL10\/Cr was associated with onset of graft\u2010associated BL. We were not able to confirm a general association of EBV viral load and urinary CXCL10. As non\u2010invasive monitoring is implemented using biomarkers like CXCL10 in the clinic, attention will be needed to identify other uncommon, potential sources of CXCL10 elevation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14354","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T11:53:50Z","timestamp":1658577230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High urinary <scp>CXCL10<\/scp>\/Cr with onset of Burkitt lymphoma in a pediatric kidney transplant recipient"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-7913","authenticated-orcid":false,"given":"Shwetha","family":"Suresh","sequence":"first","affiliation":[{"name":"The University of British Columbia Faculty of Medicine  Vancouver British Columbia 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