{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:23:02Z","timestamp":1790230982453,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>BKV\u2010HC is one of the most significant complications of HSCT. This retrospective study aimed to determine the frequency of BKV\u2010HC in pediatric patients undergoing HSCT, detect the associated risk factors for the development of BKV\u2010HC, and explore the effects of post\u2010transplantation Cy use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three hundred twenty\u2010seven patients (girls: 121, boys: 206) were analyzed according to sex, conditioning regimen, transplantation type, donor relatedness, stem cell source, the presence and grade of aGVHD, CMV co\u2010existence, and Cy use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis confirmed the prognostic importance of age (OR: 4.865), TBI use, the presence of aGVHD (OR: 2.794), CMV coinfection (OR: 2.261), and Cy use (OR: 27.353). A statistically significant difference was found between the mean BKV\u2010HC follow\u2010up times compared with post\u2010transplantation Cy intake (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). The BKV\u2010HC rate increased as the number of risk factors of the patient increased.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BKV\u2010HC is an essential complication of HSCT primarily associated with Cy use, the presence of aGVHD, and donor relatedness. The present study shows that the use of Cy in the post\u2010transplantation period further increases BKV\u2010HC risk in pediatric patients, regardless of dose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.14364","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T04:34:20Z","timestamp":1658205260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of the risk factors for\n                    <scp>BK<\/scp>\n                    virus\u2010associated hemorrhagic cystitis in pediatric bone marrow transplantation patients: Does\n                    <scp>post\u2010transplantation<\/scp>\n                    cyclophosphamide increase the frequency?"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-9849","authenticated-orcid":false,"given":"Gizem Zengin","family":"Ersoy","sequence":"first","affiliation":[{"name":"Alt\u0131nba\u015f University Medical Park Bah\u00e7elievler Hospital Pediatric Hematology Oncology &amp; Pediatric Bone Marrow Transplantation Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyhun","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Medical Park Bah\u00e7elievler Hospital Pediatric Hematology Oncology &amp; Pediatric Bone Marrow Transplantation Unit \u0130stinye University Pediatric Hematology Oncology  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-2101","authenticated-orcid":false,"given":"Basak Adakli","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Alt\u0131nba\u015f University Medical Park Bah\u00e7elievler Hospital Pediatric Hematology Oncology &amp; Pediatric Bone Marrow Transplantation Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem Ba\u015fo\u011flu","family":"\u00d6ner","sequence":"additional","affiliation":[{"name":"Alt\u0131nba\u015f University Medical Park Bah\u00e7elievler Hospital Pediatric Hematology Oncology &amp; Pediatric Bone Marrow Transplantation Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selime","family":"Aydo\u011fdu","sequence":"additional","affiliation":[{"name":"Umraniye Research &amp; Training Hospital Pediatric Hematolgy &amp; Oncology Department Medical Sciences University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"\u00c7ipe","sequence":"additional","affiliation":[{"name":"Alt\u0131nba\u015f University Medical Park Bah\u00e7elievler Hospital Pediatric Allergy\u2010Immunology &amp; Pediatric Bone Marrow Transplantation Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"S\u00fct\u00e7\u00fc","sequence":"additional","affiliation":[{"name":"\u0130stinye University Pediatric Infectious Diseases  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"\u00d6zkaya","sequence":"additional","affiliation":[{"name":"\u0130stinye University Pediatric Nephrology  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun\u00e7","family":"F\u0131\u015fg\u0131n","sequence":"additional","affiliation":[{"name":"Alt\u0131nba\u015f University Medical Park Bah\u00e7elievler Hospital Pediatric Hematology Oncology &amp; Pediatric Bone Marrow Transplantation Unit  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.12.009"},{"key":"e_1_2_10_3_1","first-page":"12","article-title":"ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus\u2010associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients","volume":"73","author":"Cesaro S","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12136"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.01.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13601"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2021.0104"},{"key":"e_1_2_10_8_1","unstructured":"HaydenRT GuZ LiuW et al.Critical revision of article Data Collection W Liu: Statistics Data Analysis\/Interpretation Drafting Article Critical Revision of Article R Lovins: Data Collection Drafting Article Critical Revision of Article K Kasow: Concept\/Design Drafting Artic2015;17(2):234\u2013241. doi:10.1111\/tid.12364.Risk. 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