{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:26Z","timestamp":1753879406490,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute kidney injury (AKI) is common in pediatric patients undergoing liver transplantation (LT), with an incidence 17%\u201355%. Fluid, metabolic, and acid\u2013base aberrancies are often pronounced pre\u2010operatively and further worsened by events during LT, making intra\u2010operative continuous renal replacement therapy (CRRT) an option for critically ill LT recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All pediatric LT performed at our institution who underwent intra\u2010operative CRRT between January 2017 and August 2021 were included. Patient demographics and clinical data including graft outcomes, intra\u2010operative findings, and timing and indications for CRRT were collected from the electronic medical record.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CRRT was used in nine of the 76 (12%) pediatric LT performed at our center during the study period. Ages at LT ranged from 39 to 17.7\u2009years. Recipients requiring CRRT were more likely to have acute liver failure, status 1A, and higher calculated MELD\/PELD scores. CRRT was initiated pre\u2010transplant in three recipients and continued post\u2010transplant in six recipients. Median duration of CRRT was two (range 0\u201314) days. Indications included hyperammonemia (3\/9), acidosis (3\/9), fluid overload (6\/9), and hyperkalemia (2\/9). The CRRT group had a significantly longer post\u2010transplant intensive care unit length of stay in comparison to those that did not require CRRT (median 6, range 3\u201340\u2009days vs. median 3, range 0\u2013121\u2009days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02], but there were no significant differences in reoperations, hospital length of stay, or recipient or graft survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrate that CRRT can be safely performed in pediatric LT recipients, including young infants through adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14377","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T10:24:13Z","timestamp":1660299853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful use of intra\u2010operative continuous renal replacement therapy in pediatric liver transplant recipients: Single center case series"],"prefix":"10.1111","volume":"26","author":[{"given":"Eliza","family":"Blanchette","sequence":"first","affiliation":[{"name":"Division of Pediatric Nephrology Department of Pediatrics Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Pahlavan","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6993-255X","authenticated-orcid":false,"given":"Dor","family":"Yoeli","sequence":"additional","affiliation":[{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE) Department of Surgery University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Division of Abdominal Transplant Surgery Department of Surgery Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-8042","authenticated-orcid":false,"given":"Dania","family":"Brigham","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition The Digestive Health Institute Department of Pediatric Medicine Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sater","sequence":"additional","affiliation":[{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE) Department of Surgery University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wachs","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE) Department of Surgery University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5405-0391","authenticated-orcid":false,"given":"Margret","family":"Bock","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Department of Pediatrics Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-1593","authenticated-orcid":false,"given":"Megan","family":"Adams","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE) Department of Surgery University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.07.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12596"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12224"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12759"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002137"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.11.026"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.03.094"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.883929"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25773"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334149"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-017-2395-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29488"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512100"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.09.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp595"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"74","article-title":"Continuous venovenous hemofiltration in neonates with hyperammonemia. A case series","volume":"89","author":"Cavagnaro Santa Mar\u00eda F","year":"2018","journal-title":"Rev Chil Pediatr"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002908"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T10:03:41Z","timestamp":1724839421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,12]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/petr.14377"],"URL":"https:\/\/doi.org\/10.1111\/petr.14377","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2022,8,12]]},"assertion":[{"value":"2022-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14377"}}