{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:58:32Z","timestamp":1775509112829,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This document is designed to outline the definition, pathogenesis, diagnostic modalities and therapeutic measures to treat antibody\u2010mediated rejection in children postheart transplant<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature review was conducted by a Pediatric Heart Transplant Society (PHTS) working group to identify existing pediatric and adult studies on antibody\u2010mediated rejection (AMR). In addition, the centers participating in PHTS were asked to submit their approach to diagnosis and management of pediatric AMR. This document synthesizes information gathered from both these sources to highlight a practical approach to diagnosing and managing a child with AMR postheart transplant. This document may not represent the practice at all centers in the PHTS and serves as a starting point to understand an approach to this clinical scenario.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14398","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T07:41:51Z","timestamp":1668498111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical approach to antibody\u2010mediated rejection from the pediatric heart transplant society"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2540-5672","authenticated-orcid":false,"given":"Shahnawaz","family":"Amdani","sequence":"first","affiliation":[{"name":"Pediatric Heart Failure and Transplant Cardiologist Cleveland Clinic Children's Hospital  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Henderson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-2282","authenticated-orcid":false,"given":"Melanie D.","family":"Everitt","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado University of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Beasley","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology; and The Heart Institute at Le Bonheur Children's Hospital University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Shih","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernat","family":"Exil","sequence":"additional","affiliation":[{"name":"Carver School of Medicine University of Iowa Stead Family Children's Hospital  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7653-6114","authenticated-orcid":false,"given":"Juan","family":"Alejos","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Mattel Children's Hospital  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Wallis","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Levine Children's Hospital  Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-8622","authenticated-orcid":false,"given":"Estela","family":"Azeka","sequence":"additional","affiliation":[{"name":"Unidade de Cardiologia Heart Institute (InCor) University of S\u00e3o Paulo Medical School  Cerqueira C\u00e9sar Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0144-1433","authenticated-orcid":false,"given":"Deipanjan","family":"Nandi","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital The Ohio State University  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-3346","authenticated-orcid":false,"given":"Elizabeth","family":"Profita","sequence":"additional","affiliation":[{"name":"Stanford University Lucile Packard Children's Hospital Stanford  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-6252","authenticated-orcid":false,"given":"Joseph","family":"Spinner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Texas Children's Hospital  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Defne","family":"Magnetta","sequence":"additional","affiliation":[{"name":"unidade de cardiologia Ann &amp; Robert H. 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