{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:43Z","timestamp":1753879363616,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of renal replacement therapy (RRT) on the long\u2010term survival outcomes of pediatric liver recipients remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 224 patients aged &lt;18\u2009years, who underwent liver transplantation (LT), were divided into two groups: patients who underwent renal replacement therapy (RRT) (group R, <jats:italic>n<\/jats:italic>\u00a0=\u00a025, 11.2%) and those who did not (group N, <jats:italic>n<\/jats:italic>\u00a0=\u00a0199, 88.8%). The posttransplant patient survival outcomes according to RRT use constituted the primary end\u2010point. RRT was initiated preoperatively in 12 patients (48.0%) and postoperatively in 13 [early: &lt;6\u2009months after LT (<jats:italic>n<\/jats:italic>\u00a0=\u00a05, 20.0%) and late: \u22656\u2009months after LT (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 32.0%)]. The indications for RRT included liver disease involving the kidney (44.0%) and hepatorenal syndrome (56.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The age at the time of LT (71.6 vs. 19.1\u2009months) was higher, the pediatric end\u2010stage liver disease score was lower (9.9 vs. 21.2), and the duration of hospitalization posttransplantation (41.0 vs. 27.0\u2009days) was longer, while the rates of hepatic artery thrombosis (8.0% vs. 3.5%) were higher in group R (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The number of patients (60.0% vs. 93.0%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and graft survival rates (68.0% vs. 93.0%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) were significantly lower in group R. Multivariate analysis revealed that posttransplant RRT and hepatic artery complications were risk factors for patient survival outcomes. Renal function was recovered in 7 patients (28.0%) in group R, and 9 (36.0%) eventually underwent kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The survival outcomes of children requiring posttransplant RRT were significantly worse than those of children, who did not undergo RRT. Physicians should pay meticulous attention to patients requiring post\u2010LT RRT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14422","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T06:25:35Z","timestamp":1667456735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>Posttransplant<\/scp> renal replacement therapy is an alarm signal for survival outcomes in pediatric liver transplantation"],"prefix":"10.1111","volume":"27","author":[{"given":"Byung Min","family":"Yoo","sequence":"first","affiliation":[{"name":"Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Young","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University College of Medicine  Seoul South 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