{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:03:38Z","timestamp":1758816218339,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL147957"],"award-info":[{"award-number":["R01HL147957"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mechanical ventilation prior to pediatric heart transplantation predicts inferior post\u2010transplant survival, but the impact of ventilation <jats:italic>duration<\/jats:italic> on survival is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the United Network for Organ Sharing and Pediatric Health Information System were used to identify pediatric (&lt;18\u2009years) heart transplant recipients from 2003 to 2020. Patients ventilated pretransplant were first compared to no ventilation, then ventilation durations were compared across quartiles of ventilation (\u22641\u2009week, 8\u2009days\u20135\u2009weeks, &gt;5\u2009weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At transplant, 11% (511\/4506) of patients required ventilation. Ventilated patients were younger, had more congenital heart disease, more urgent listing\u2010status, and greater rates of nephropathy, TPN\u2010dependence, and inotrope and ECMO requirements (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001 for all). Post\u2010transplant, previously ventilated patients experienced longer ventilation durations, ICU and hospital stays, and inferior survival (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). Hospital outcomes and survival worsened with longer pretransplant ventilation. One\u2010year and overall survival were similar between the no\u2010ventilation and \u22641\u2009week groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.703 &amp; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.433, respectively) but were significantly worse for ventilation durations &gt;1\u2009week (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). On multivariable analysis, ventilation \u22641\u2009week did not predict mortality (HR 0.98 [95% CI 0.85\u20131.43]), whereas ventilation &gt;1\u2009week did (HR: 1.18 [1.01\u20131.39]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longer pretransplant ventilation portends worse outcomes, although only ventilation &gt;1\u2009week predicts mortality. These findings can inform pretransplant prognostication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14433","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T05:01:04Z","timestamp":1667883664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Not all durations of preheart transplant mechanical ventilation portend inferior post\u2010transplant survival in children"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-0587","authenticated-orcid":false,"given":"Jason W.","family":"Greenberg","sequence":"first","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-1499","authenticated-orcid":false,"given":"Kevin","family":"Kulshrestha","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-1603","authenticated-orcid":false,"given":"Alia","family":"Dani","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8005-3361","authenticated-orcid":false,"given":"David S.","family":"Winlaw","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-727X","authenticated-orcid":false,"given":"David G.","family":"Lehenbauer","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8344-8991","authenticated-orcid":false,"given":"Clifford","family":"Chin","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-5456","authenticated-orcid":false,"given":"Angela","family":"Lorts","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-670X","authenticated-orcid":false,"given":"Katja M.","family":"Gist","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-7242","authenticated-orcid":false,"given":"Farhan","family":"Zafar","sequence":"additional","affiliation":[{"name":"The Heart Institute, Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-1777","authenticated-orcid":false,"given":"David L. 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