{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:38:35Z","timestamp":1792636715115,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Argentina, Hemolytic uremic syndrome caused by Shiga toxin\u2010producing <jats:italic>Escherichia coli<\/jats:italic> (STEC HUS), is the main cause of acute kidney injury and the second cause of end\u2010stage renal disease (ESRD) in children. In recent decades, strategies have been implemented to reduce progression to ESRD, but it is not known whether the cumulative incidence of HUS requiring kidney transplantation (KTx) has decreased. We aimed to determine whether the cumulative incidence of STEC HUS in children undergoing KTx decreased and compared outcomes of HUS\u2010related KTx vs. those related to other etiologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients who underwent KTx at our institution were evaluated. The cohort was divided into quintiles (Q), and we compared the cumulative incidence of HUS\u2010related KTx vs KTx due to other etiologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1000 consecutive KTx were included. The cumulative incidence of HUS\u2010related KTx was 11%. HUS was the second cause of KTx in Q1: 17% (1988\u20131995); Q2: 13.5% (1996\u20132003); Q3: 11.5% (2004\u20132009) and third cause in Q4: 10% (2010\u20132015) and Q5: 3% (2016\u20132021). The cumulative incidence of HUS\u2010related KTx decreased in Q4 and Q5 compared to Q1, Q2, and Q3 and the decline was even steeper when comparing Q4 to Q5 (p:0.019). There was no difference in graft survival in patients with HUS vs. congenital anomalies of kidney and urinary tract (CAKUT) but better than in those with focal segmental glomerulosclerosis (FSGS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this cohort, the cumulative incidence of HUS\u2010related KTx decreased, which may have been due to the implementation of nephroprotective strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14489","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T05:00:45Z","timestamp":1677733245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A decrease in the incidence of Shiga toxin\u2010related hemolytic uremic syndrome as a cause of kidney transplantation at an argentine referral center"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-2066","authenticated-orcid":false,"given":"Marta L.","family":"Monteverde","sequence":"first","affiliation":[{"name":"Nephrology Department, Renal Transplant Unit Hospital de Pediatria J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Panero","sequence":"additional","affiliation":[{"name":"Nephrology Department, Renal Transplant Unit Hospital de Pediatria J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia B.","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Nephrology Department, Renal Transplant Unit Hospital de Pediatria J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Locane","sequence":"additional","affiliation":[{"name":"Nephrology Department, Renal Transplant Unit Hospital de Pediatria J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sarkis","sequence":"additional","affiliation":[{"name":"Infectology and Epidemiology Department Hospital de Pediatria J.P Garrahan  CABA Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana A.","family":"Mattio","sequence":"additional","affiliation":[{"name":"Department of Statistics Hospital de Pediatria J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan P.","family":"Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Nephrology Department, Renal Transplant Unit Hospital de Pediatria J.P Garrahan  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036079"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330608"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(64)80337-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.90.4.616"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.09717.x"},{"key":"e_1_2_8_7_1","first-page":"552","article-title":"Chronic kidney disease, dialysis and transplant. multicenter study: 1996 \u2013 2003","volume":"6","author":"Grimoldi I","year":"2008","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13763"},{"key":"e_1_2_8_9_1","unstructured":"Bolet\u00edn Integrado de Vigilancia N\u00b0 487\u2013SE 08\/2020. Available online:http:\/\/www.msal.gob.ar\/images\/stories\/boletines\/Boletin\u2010Integrado\u2010De\u2010Vigilancia\u2010N487\u2010SE8. Page Visited 11\/20\/2022."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80073-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1451-y"},{"key":"e_1_2_8_12_1","first-page":"1148","article-title":"Two different therapeutic regimes in patients with sequelae of hemolytic\u2010uremic syndrome","volume":"10","author":"Caletti MG","year":"2004","journal-title":"Pediatr Nephrol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1867-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-0936-9"},{"key":"e_1_2_8_15_1","unstructured":"https:\/\/sintra.incucai.gov.ar\/. 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