{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:12:47Z","timestamp":1758892367643,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>There is limited data examining donor vasopressor and\/or inotrope medications (vasoactives) on pediatric orthotopic heart transplant (OHT) outcomes. We aim to evaluate the effects of vasoactives on pediatric OHT outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The United Network for Organ Sharing database was retrospectively reviewed from January 2000 to March 2018 for donor hearts. Exclusion criteria included multiorgan transplants and recipient age\u2009&gt;18. Donors receiving vasoactives at the time of procurement were compared to donors not on vasoactives, including the number of vasoactives and the type. End\u2010points of interest were survival at 30\u2009days and 1\u00a0year as well as post\u2010transplant rejection at 1\u00a0year. Logistic and Cox models were used to quantify survival end\u2010points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 6462 donors, 3187 (49.3%) were receiving at least one vasoactive. Comparing any vasoactive medication versus none, there was no difference in 30\u2010day survival (<jats:italic>p<\/jats:italic>\u00a0=\u2009.27), 1\u2009year survival (<jats:italic>p<\/jats:italic>\u00a0=\u2009.89), overall survival (<jats:italic>p<\/jats:italic>\u00a0=\u2009.68), or post\u2010transplant rejection (<jats:italic>p<\/jats:italic>\u00a0=\u2009.98). There was no difference in 30\u2010day survival for donors receiving 2 or more vasoactive infusions (<jats:italic>p<\/jats:italic>\u00a0=\u2009.89), 1\u2009year survival (<jats:italic>p<\/jats:italic>\u00a0=\u2009.53), overall survival (<jats:italic>p<\/jats:italic>\u00a0=\u2009.75), or post\u2010transplant rejection at 1\u00a0year (<jats:italic>p<\/jats:italic>\u00a0=\u2009.87). Vasopressin was associated with decreased 30\u2010day mortality (OR\u00a0=\u00a00.22; <jats:italic>p<\/jats:italic>\u00a0=\u2009.028), dobutamine with decreased 1\u2010year mortality (OR\u00a0=\u00a00.37; <jats:italic>p<\/jats:italic>\u00a0=\u2009.036), overall survival (HR\u00a0=\u00a00.51; <jats:italic>p<\/jats:italic>\u00a0=\u2009.003), and decreased post\u2010transplant rejection (HR\u00a0=\u00a00.63; <jats:italic>p<\/jats:italic>\u00a0=\u2009.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no difference in pediatric OHT outcomes when the cardiac donor is treated with vasoactive infusions at procurement. Vasopressin and dobutamine were associated with improved outcomes. This information can be used to guide medical management and donor selection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14500","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T02:13:49Z","timestamp":1678500829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Do vasoactive medications impact donor hearts clinical outcomes in pediatric heart transplantation?"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-5470","authenticated-orcid":false,"given":"David","family":"Blitzer","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Cardiovascular Surgery Columbia University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Lirette","sequence":"additional","affiliation":[{"name":"Fulcrum  Jackson Mississippi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Kane","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery TransMedics, Inc.  Andover Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack G.","family":"Copeland","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Arizona  Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Baran","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Heart Vascular and Thoracic Institute  Weston Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-5194","authenticated-orcid":false,"given":"Hannah","family":"Copeland","sequence":"additional","affiliation":[{"name":"Lutheran Hospital  Fort Wayne Indiana USA"},{"name":"Indiana University School of Medicine \u2013 Fort Wayne  Fort Wayne Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_2_1","DOI":"10.1016\/j.cardfail.2012.03.001"},{"doi-asserted-by":"publisher","key":"e_1_2_11_3_1","DOI":"10.1016\/j.healun.2015.08.002"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_1","DOI":"10.1111\/petr.13676"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.1016\/j.ejcts.2011.04.042"},{"doi-asserted-by":"publisher","key":"e_1_2_11_6_1","DOI":"10.1016\/j.healun.2016.11.009"},{"doi-asserted-by":"publisher","key":"e_1_2_11_7_1","DOI":"10.1056\/NEJM200103153441102"},{"doi-asserted-by":"publisher","key":"e_1_2_11_8_1","DOI":"10.1111\/j.1399-3046.2010.01300.x"},{"doi-asserted-by":"publisher","key":"e_1_2_11_9_1","DOI":"10.1161\/CIRCULATIONAHA.114.009120"},{"doi-asserted-by":"publisher","key":"e_1_2_11_10_1","DOI":"10.1111\/petr.12149"},{"doi-asserted-by":"publisher","key":"e_1_2_11_11_1","DOI":"10.1016\/j.healun.2017.07.018"},{"doi-asserted-by":"publisher","key":"e_1_2_11_12_1","DOI":"10.1111\/tri.12221"},{"doi-asserted-by":"publisher","key":"e_1_2_11_13_1","DOI":"10.1097\/01.TP.0000045683.85282.93"},{"doi-asserted-by":"publisher","key":"e_1_2_11_14_1","DOI":"10.1097\/TP.0000000000001059"},{"doi-asserted-by":"publisher","key":"e_1_2_11_15_1","DOI":"10.1111\/petr.13216"},{"doi-asserted-by":"publisher","key":"e_1_2_11_16_1","DOI":"10.1111\/tri.12835"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14500","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T12:54:56Z","timestamp":1725627296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/petr.14500"],"URL":"https:\/\/doi.org\/10.1111\/petr.14500","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2023,3,10]]},"assertion":[{"value":"2022-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14500"}}