{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:57:36Z","timestamp":1777485456624,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Retinoblastoma (RB) is the most common intraocular malignancy in childhood. Advanced RB, associated with exceedingly poor prognosis, requires more intensive multiagent chemotherapy than conventional regimens. Rescue of the bone marrow after intensive chemotherapy is achieved with stem cell transplantation. The sequential courses (tandem transplantation) of high\u2010dose chemotherapy followed by autologous stem cell transplantation allow for even greater dose intensity in consolidation with the potential to use different active chemotherapeutics at each transplant and have proven feasible and successful in treating children with recurrent\/refractory solid tumors.<\/jats:p><\/jats:sec>Case Description<\/jats:title>We report an infant with trilateral high\u2010risk RB who received tandem high\u2010dose chemotherapy (HDC) followed by autologous stem cell transplantation after the conventional chemotherapy. A 5\u2010month\u2010old female patient presented with strabismus, and the ophthalmoscopic examination showed intraocular tumoral lesions in both eyes. Magnetic resonance imaging (MRI) concluded the trilateral retinoblastoma diagnosis due to a tumoral mass in the optic chiasm. The follow\u2010up ophthalmologic examinations and the MRI detected stable disease after six cycles of multiagent chemotherapy.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Rescue with autologous stem cell transplantation after HDC allows for an increase in chemotherapy intensity. Tandem transplantation provides the chance to perform different chemotherapeutics at each transplant and enables an increase in the chemotherapy intensity, thus providing a positive effect on disease\u2010free survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14504","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T09:33:11Z","timestamp":1678872791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tandem high\u2010dose chemotherapy followed by autologous stem cell transplantation: An infant with trilateral retinoblastoma"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6379-8326","authenticated-orcid":false,"given":"Ersin","family":"Toret","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Eskisehir Osmangazi University, School of Medicine Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9172-9627","authenticated-orcid":false,"given":"Zeynep Canan","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Eskisehir Osmangazi University, School of Medicine Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-9849","authenticated-orcid":false,"given":"Gizem","family":"Zengin\u00a0Ersoy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Altinbas University, School of Medicine, Medicalpark Bahcelievler Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0451-9400","authenticated-orcid":false,"given":"Cigdem","family":"Oztunali","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology Eskisehir Osmangazi University, School of Medicine Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6771-9894","authenticated-orcid":false,"given":"Ceyhun","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Istinye University, School of Medicine, Alt\u0131nbas University Medicalpark Bahcelievler Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4344-8174","authenticated-orcid":false,"given":"Rejin","family":"Kebudi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology Istanbul University Oncology Institute, Cerrahpasa School of Medicine Istanbul 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