{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:50:56Z","timestamp":1792219856032,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Haploidentical hematopoietic stem cell transplantation (HSCT) with depletion of \u03b1\u03b2<jats:sup>+<\/jats:sup> T cells and CD19<jats:sup>+<\/jats:sup> B cells has emerged as a viable alternative to traditional donors for treating acute leukemia in children. As the use of this innovative approach continues to grow and more experience is gained, it is essential to identify and comprehend the key factors that contribute to successful transplantation and improved outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of single\u2010center data from 27 children with acute lymphoblastic leukemia and 11 children with acute myeloid leukemia who underwent haploidentical HSCT with depletion of \u03b1\u03b2<jats:sup>+<\/jats:sup> T cells and CD19<jats:sup>+<\/jats:sup> B cells between the years 2013 and 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Engraftment was successful in 34 out of 38 patients (90%). The 5\u2010year overall survival and event\u2010free survival rates were 51% and 42%, respectively. There were no cases of grade III\u2013IV acute graft\u2010versus\u2010host disease, and only two patients developed chronic graft\u2010versus\u2010host disease. Patients with a higher content of \u03b3\u03b4<jats:sup>+<\/jats:sup> T cells in the graft demonstrated a longer event\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\u03b1\u03b2<jats:sup>+<\/jats:sup>\/CD19<jats:sup>+<\/jats:sup>\u2010depleted haploidentical hematopoietic stem cell transplantation can offer long\u2010term remission for children with acute leukemia with minimal graft\u2010versus\u2010host disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14531","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T04:56:13Z","timestamp":1683003373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["\u03b1\u03b2<sup>+<\/sup>\/<scp>CD19<\/scp><sup>+<\/sup>\u2010depleted haploidentical stem cell transplantation for children with acute leukemia: Is there a protective effect of increased \u03b3\u03b4<sup>+<\/sup> T\u2010cell content in the graft?"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4502-0625","authenticated-orcid":false,"given":"Gal","family":"Dadi","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Sheba Medical Center The Edmond and Lily Safra Children's Hospital  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1411-8942","authenticated-orcid":false,"given":"Elad","family":"Jacoby","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Sheba Medical Center The Edmond and Lily Safra Children's Hospital  Ramat Gan Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etai","family":"Adam","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Sheba Medical Center The Edmond and Lily Safra Children's Hospital  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna","family":"Hutt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Sheba Medical Center The Edmond and Lily Safra Children's Hospital  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nira","family":"Varda\u2010Bloom","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory Sheba Medical Center  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-6439","authenticated-orcid":false,"given":"Bella","family":"Bielorai","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Sheba Medical Center The Edmond and Lily Safra Children's Hospital  Ramat Gan Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Toren","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Sheba Medical Center The Edmond and Lily Safra Children's Hospital  Ramat Gan Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.34"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2011.04.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702996"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8146660"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103710"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-007-9004-4"},{"issue":"5","key":"e_1_2_10_8_1","first-page":"503","article-title":"Increased frequency of TCR\u03b3\u03b4+ T cells in disease\u2010free survivors following T cell\u2010depleted, partially mismatched, related donor bone marrow transplantation for leukemia","volume":"5","author":"Lamb LS","year":"1996","journal-title":"J Hematother Stem Cell 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