{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:29:17Z","timestamp":1788802157810,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>People with group O blood are considered universal organ donors compatible with any other blood group. However, in the case of minor ABO\u2010incompatible transplantation, immune\u2010mediated hemolysis may occur due to concomitant transfer of donor B lymphocytes together with the allograft. These passenger lymphocytes can produce antibodies in the recipients erythrocytes, causing hemolytic anemia known as passenger lymphocyte syndrome (PLS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 6\u2010year\u2010old boy (A+) underwent transplantation of a kidney from his father (O+). On postoperative day (POD) 6, the patient developed fever with no explainable causes. On POD 11, he presented with abdominal pain, hematochezia, and severe diarrhea, with sudden hemolytic anemia. Since then, GI symptoms have continued. On POD 20, direct antiglobulin test (DAT) was positive, and the anti\u2010A IgM\/G titer was 2\/32. The results of the anti\u2010A antibody elution test were strongly positive (3+). These findings highly suggested PLS. On the same day, the GI symptoms suddenly worsened, and laboratory findings showed hemolysis and thrombocytopenia with disseminated intravascular coagulation (DIC). Abdominal computed tomography (CT) scans suggested ischemic colitis of venous origin, and the patient underwent segmental colectomy with ileostomy formation on POD 23. To remove the anti\u2010A antibodies, the patient underwent therapeutic plasma exchange (TPE) five times until the DAT and anti\u2010A elution test were negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report a case of gastrointestinal involvement of PLS that occurred after minor ABO\u2010incompatible kidney transplantation. This is the first report of ischemic colitis as an atypical manifestation of PLS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14556","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T05:50:13Z","timestamp":1686376213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gastrointestinal involvement of passenger lymphocyte syndrome followed by minor <scp>ABO<\/scp>\u2010incompatible renal transplantation: A case report"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5713-569X","authenticated-orcid":false,"given":"Gyeong Eun","family":"Yeom","sequence":"first","affiliation":[{"name":"Departments of Pediatrics Seoul National University Children's Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Hee","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Pusan National University Children's Hospital and School of Medicine  Yangsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo Han","family":"Ahn","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Seoul National University Children's Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungsuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongwon","family":"Ha","sequence":"additional","affiliation":[{"name":"The Transplantation Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University Children's Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Gyung","family":"Kang","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Seoul National University Children's Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/715769"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31191096190.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282e9a576"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41030365.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00026.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14086"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.06.004"},{"key":"e_1_2_8_9_1","unstructured":"Seoul National University Hospital Transplant Center. 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