{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:20:02Z","timestamp":1759335602532,"version":"3.41.2"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several studies describe poorer motor developmental motor outcomes post\u2010liver transplant (LT) in younger children. Limited studies examine physical function in older children and adolescents pre\u2010 and post\u2010LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of standard of care physical function outcome measures pre\u2010 and 1\u2010year post\u2010LT in children \u22656\u2009years at LT. Measures include: 6\u2010minute walk test (6MWT), grip strength, Bruininks\u2010Oseretsky Test of Motor Proficiency\u20102 (BOT\u20102) components, Physical Activity Questionnaire (PAQ), and Paediatric Quality of Life Multidimensional Fatigue Scale. Association of medical variables with outcomes was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort included 23 (8 male, median (interquartile range) age 11.67 (8.25, 13.92) years at LT) participants. Top two primary diagnoses included biliary atresia (30.4%) and fulminant hepatic failure (21.7%). At 1\u2010year post\u2010LT, over one\u2010third (36%) were overweight or obese. Compared with healthy norms, children had significantly lower pre\u2010LT PAQ scores (<jats:italic>p<\/jats:italic>\u2009=\u2009.002), pre\u2010 and post\u20106MWT scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and post\u2010LT BOT\u20102 strength and agility scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Pre\u2010LT, lower balance scores were associated with abdominal distention\/ascites (<jats:italic>p<\/jats:italic>\u2009=\u2009.009) and splenomegaly (<jats:italic>p<\/jats:italic>\u2009=\u2009.017). Lower pre\u2010LT platelet count correlated with poorer balance (<jats:italic>r<\/jats:italic>\u2009=\u2009.532, <jats:italic>p<\/jats:italic>\u2009=\u2009.017) and lower strength and agility scores (<jats:italic>r<\/jats:italic>\u2009=\u2009.446, <jats:italic>p<\/jats:italic>\u2009=\u2009.043). Significant moderate inverse correlations were found between weight\/body mass index <jats:italic>z<\/jats:italic>\u2010scores and BOT\u20102 components. Post\u2010LT children continue to demonstrate decreased levels of motor proficiency and functional capacity but report less fatigue and increased physical activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Older children and adolescents undergoing LT are at risk of decreased physical function, highlighting the need for pre\u2010 and post\u2010LT rehabilitation to optimize long term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14573","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T07:42:10Z","timestamp":1690357330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Physical function in children and adolescents pre\u2010 and 1\u2010year post\u2010liver transplant"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-5144","authenticated-orcid":false,"given":"Catherine","family":"Patterson","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Transplant and Regenerative Medicine Centre The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"So","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Transplant and Regenerative Medicine Centre The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitie","family":"Shipley","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline E.","family":"Shivgulam","sequence":"additional","affiliation":[{"name":"Division of Kinesiology, School of Health and Human Performance, Faculty of Health Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Avitzur","sequence":"additional","affiliation":[{"name":"Transplant and Regenerative Medicine Centre The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"},{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9998-5692","authenticated-orcid":false,"given":"Vicky Lee","family":"Ng","sequence":"additional","affiliation":[{"name":"Transplant and Regenerative Medicine Centre 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