{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:07:01Z","timestamp":1791824821530,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Domino liver transplant (DLT) represents another type of liver donor to expand the donor pool. Recent reports of successful DLT in children with maple syrup urine disease (MSUD) show promising long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>It was a retrospective study. All children with MSUD were paired with either recipients with end\u2010stage liver disease (ESLD) or non\u2010MSUD metabolic disease. Each pair underwent simultaneous liver transplant (LT), where the MSUD recipient received the graft from a living\u2010related donor and the liver explanted from the MSUD donor was transplanted to the respective paired domino recipient. We report our experience regarding the techniques and outcomes of DLT at our center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven children with MSUD and 12 respective DLT recipients were enrolled, one of which was domino split\u2010liver transplantation. DLT recipients included seven ESLD, two propionic acidemia (PA), one glycogen storage disease(GSD) type\u20101, one GSD type\u20103, and one Citrullinemia. Post\u2010LT ICU and hospital stays were comparable (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). Patient and graft survival was 100% and 66.6% in the MSUD group and DLT recipients at a mean follow\u2010up of 13.5 and 15\u2009months. There was no death in the MSUD group as compared to four in the DLT group. The amino acid levels rapidly normalized after the LT in the children with MSUD and they tolerated the normal unrestricted diet. No vascular, biliary, or graft\u2010related complications were seen in the post\u2010transplant period. No occurrence of MSUD was noted in DLT recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DLTs have excellent post\u2010surgical outcomes. DLT should be strongly considered and adopted by transplant programs worldwide to circumvent organ shortage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14603","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:10:00Z","timestamp":1693631400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Domino liver transplantation for maple syrup urine disease in children: A single\u2010center case series"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9551-5220","authenticated-orcid":false,"given":"Vikram","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pediatric Hepatology, Centre for Liver and Biliary Sciences Max Super Speciality Hospital  New Delhi 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