{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:03:17Z","timestamp":1788397397373,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiovascular events are one of the most important causes of morbidity and mortality in the long\u2010term follow\u2010up of liver transplant recipients. Hypertension is a significant cardiovascular risk factor that occurs frequently after pediatric liver transplantation. Chronic use of immunosuppressants \u2013 mainly calcineurin inhibitors \u2013 plays a major role in the development of post\u2010transplant hypertension and circadian disturbances such as flattening of the nocturnal blood pressure dip. This requires special attention in children given the long timeframe during which immunosuppressive therapy is necessary. Careful and structured blood pressure monitoring and adequate treatment of hypertension are essential to optimize the quality of life and life expectancy of pediatric liver transplant patients. However, evidence\u2010based guidelines for monitoring and management of post\u2010transplant hypertension and its complications are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a comprehensive review of the current knowledge and practices concerning post\u2010transplant hypertension. The databases Pubmed, Embase, Web of Science and Google Scholar were scanned with the following keywords: pediatric liver transplantation, immunosuppression, tacrolimus, cardiovascular effects, hypertension, heart function, kidney function, circadian rhythm, mechanism, monitoring, and management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this review, we describe the incidence and etiology of hypertension in pediatric liver transplant recipients, the underlying mechanisms and characteristics of calcineurin inhibitor\u2010induced hypertension, and the consequences of and risk factors for post\u2010transplant hypertension. We hereby present an overview of the current practices in blood pressure monitoring and antihypertensive treatment as well as an algorithm for the evaluation and management of hypertension post liver transplantation. Finally, we discuss knowledge gaps and suggestions for future research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14630","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T05:35:51Z","timestamp":1698903351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Etiology, risk factors and management of hypertension post liver transplantation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5638-0717","authenticated-orcid":false,"given":"Eline","family":"Braekman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Pediatrics Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"De\u00a0Bruyne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Pediatrics Ghent University  Ghent Belgium"},{"name":"Department of Pediatric 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