{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:19:43Z","timestamp":1791937183116,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Liver transplantation (LT) is the only potentially curative option for children with unresectable hepatoblastoma (HBL). Although post\u2010transplant outcomes have improved in the contemporary era, the impact of donor graft type on survival remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the United Network for Organ Sharing database (02\/2002\u201306\/2021), demographics, clinical characteristics, and patient and graft survival were analyzed in children (&lt;18\u2009years) who underwent LT for HBL according to donor graft type. The Kaplan\u2013Meier method, log\u2010rank tests, and Cox regression modeling were used to evaluate the effect of whole, partial, and split deceased donor liver transplantation (DDLT) and living donor liver transplantation (LDLT) on patient and graft survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 590 pediatric HBL LT recipients (344 whole graft DDLT; 62 partial graft DDLT; 139 split graft DDLT; 45 LDLT) were included. During 2012\u20132021 the proportion of LDLTs for HBL decreased to about 5% compared with about 11% during 2002\u20132011. No significant differences were identified by donor graft type in either patient survival (log\u2010rank test, <jats:italic>p<\/jats:italic>\u2009=\u2009.45) or graft survival (log\u2010rank test, <jats:italic>p<\/jats:italic>\u2009=\u2009.69). The results remained similar during the 2002\u20132011 era, while during the 2012\u20132021 era, split graft DDLT was associated with decreased graft loss risk versus whole graft DDLT (hazard ratio: 0.48, 95% confidence interval: 0.23\u20130.99, <jats:italic>p<\/jats:italic>\u2009=\u2009.046) without any other significant between\u2010group differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Utilizing non\u2010whole liver grafts can increase access to LT in children with unresectable HBL while ensuring favorable outcomes. LDLT is underutilized in children with HBL in the United States, and efforts to explore LDLT options should be undertaken.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14641","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T07:22:15Z","timestamp":1699600935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of donor graft type on survival after liver transplantation for hepatoblastoma in children"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-6909","authenticated-orcid":false,"given":"Ioannis A.","family":"Ziogas","sequence":"first","affiliation":[{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE), Department of Surgery University of Colorado, Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Division of Transplant Surgery, Department of Surgery Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Schmoke","sequence":"additional","affiliation":[{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE), Department of Surgery University of Colorado, Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Division of Transplant Surgery, Department of Surgery Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6993-255X","authenticated-orcid":false,"given":"Dor","family":"Yoeli","sequence":"additional","affiliation":[{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE), Department of Surgery University of Colorado, Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Division of Transplant Surgery, Department of Surgery Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Cullen","sequence":"additional","affiliation":[{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE), Department of Surgery University of Colorado, Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Division of Transplant Surgery, Department of Surgery Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.","family":"Boster","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Liver Center, Digestive Health Institute and Section of Pediatric Gastroenterology, Hepatology &amp; Nutrition, Children's Hospital Colorado University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Wachs","sequence":"additional","affiliation":[{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE), Department of Surgery University of Colorado, Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Division of Transplant Surgery, Department of Surgery Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-1593","authenticated-orcid":false,"given":"Megan A.","family":"Adams","sequence":"additional","affiliation":[{"name":"Colorado Center for Transplantation Care, Research and Education (CCTCARE), Department of Surgery University of Colorado, Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Division of Transplant Surgery, Department of Surgery Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2007.07.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000046"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2741\/460"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-020-00421-z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000618"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02059-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0259503"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1717087"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.10376"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00354.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2708-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70272-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2022.21827"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.12.035"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3468(99)90164-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)44469-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30264"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.20607.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200209150-00011"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13305"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16978"},{"key":"e_1_2_10_23_1","first-page":"14","volume-title":"Report to the Board of Directors","author":"Pediatric Transplantation Committee","year":"2011"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v4.i4.294"},{"key":"e_1_2_10_25_1","unstructured":"Pediatric and Liver Committee.Pediatric and Liver Committees sponsor recently approved policy changes. 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