{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:58:17Z","timestamp":1777694297885,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatic undifferentiated embryonal sarcoma (HUES) is the third most common primary hepatic malignancy in children. If unresectable, liver transplantation (LT) is the only curative option. Historically, HUES LT outcomes were not favorable; however, modern\u2010era data are lacking. We aimed to describe LT outcomes in children with HUES and compared with LT outcomes in children transplanted for hepatoblastoma (HBL) and non\u2010malignancy indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children 18\u2009years or younger with HUES who underwent LT from 1987 to 2021 were identified from the Scientific Registry of Transplant Recipients database. Graft and patient survival were studied in HUES and LT recipients with HBL and non\u2010malignancy indications using Kaplan\u2013Meier analysis. Cox regression was used to compare patient and graft survival among groups, controlling for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one children with HUES underwent LT during the study period with a median age at LT of 10\u2009years (IQR: 8\u201312\u2009years). One and five\u2010year patient survival for HUES recipients was not significantly different from that of recipients with HBL (<jats:italic>p<\/jats:italic>\u2009=\u2009.3) or non\u2010malignancy diagnoses (<jats:italic>p<\/jats:italic>\u2009=\u2009.6). There were no deaths due to HUES recurrence. In multivariable Cox regression, HUES did not increase risk of either patient or graft loss as compared to HBL (HR 2.36, <jats:italic>p<\/jats:italic>\u2009=\u2009.2) or non\u2010malignancy indications (HR 0.74, <jats:italic>p<\/jats:italic>\u2009=\u2009.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LT outcomes are more favorable in patients with HUES than historically described, and similar to LT outcomes of patients with HBL and non\u2010malignancy indications. Transplant should be considered for HUES patients with unresectable localized tumors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14645","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T05:43:02Z","timestamp":1701150182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modern\u2010era successful liver transplantation outcomes in children with hepatic undifferentiated embryonal sarcoma"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-5187","authenticated-orcid":false,"given":"Priya S.","family":"Rolfes","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Liver Center, Digestive Health Institute and Section of Pediatric Gastroenterology, Hepatology &amp; Nutrition, Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6993-255X","authenticated-orcid":false,"given":"Dor","family":"Yoeli","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Department of Surgery, Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4021-5615","authenticated-orcid":false,"given":"Amy G.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Liver Center, Digestive Health Institute and Section of Pediatric Gastroenterology, Hepatology &amp; Nutrition, Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-1593","authenticated-orcid":false,"given":"Megan A.","family":"Adams","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Department of Surgery, Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3090-3652","authenticated-orcid":false,"given":"Michael E.","family":"Wachs","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, Department of Surgery, Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3061-1449","authenticated-orcid":false,"given":"Julia M.","family":"Boster","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Liver Center, Digestive Health Institute and Section of Pediatric Gastroenterology, Hepatology &amp; Nutrition, Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2018.06.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197807)42:1<336::aid-cncr2820420151>3.0.co;2-v"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.05.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318271c948"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23773"},{"key":"e_1_2_10_7_1","unstructured":"Guidance to Liver Transplant Programs and the National Liver Review Board for: Pediatric MELD\/PELD Exception Review.2023; Organ Procurement and Transplantation Network. Updated 1\/5\/23. Accessed January 5 2023.https:\/\/optn.transplant.hrsa.gov\/media\/3yqdbemu\/liver_guidance_pediatric_meld_201706.pdf"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24847"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2018.03.017"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2014.07.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16945"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000529"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-007-1265-y"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T06:17:12Z","timestamp":1724307432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/petr.14645"],"URL":"https:\/\/doi.org\/10.1111\/petr.14645","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]},"assertion":[{"value":"2023-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14645"}}