{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:03Z","timestamp":1753879383865,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hematopoietic stem cell transplantation (HSCT) is a common and effective treatment for multiple malignant and non\u2010malignant pediatric conditions. Graft\u2010versus\u2010host disease (GVHD) is a common complication of HSCT that can be prevented with prophylactic use of calcineurin inhibitor (CNI) immunosuppressants. A complication of HSCT and CNI use is pericardial effusion (PEF), which is frequently treated by CNI discontinuation with or without surgical intervention. No studies to date have evaluated the management of PEF without CNI discontinuation as a means of preventing GVHD flares.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center retrospective study, we reviewed the management of PEF in pediatric patients post\u2010HSCT who received conservative or surgical intervention with or without CNI discontinuation between May 2012 and June 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the patients found to have PEF, all were given tacrolimus for GVHD prophylaxis. Management of PEF included surgical intervention for 83% of patients, and CNI was not discontinued for 83%. None of the patients developed GVHD during the management of PEF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that continuation of CNI therapy for GVHD prophylaxis did not negatively impact the disease course of PEF in post\u2010HSCT patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14672","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T16:50:52Z","timestamp":1701535852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A fluid relationship: Calcineurin inhibitors and pericardial effusions"],"prefix":"10.1111","volume":"28","author":[{"given":"Mark Lee","family":"Westbroek","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-1979","authenticated-orcid":false,"given":"Mahvish Qureshi","family":"Rahim","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Riley Hospital for Children at Indiana University Health  Indianapolis Indiana USA"},{"name":"Department of Pediatric Hematology\/Oncology and Bone Marrow Transplantation Riley Hospital for Children  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Marshall","family":"Ross","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Pediatric Cardiology Riley Hospital for Children  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"April Leigh","family":"Rahrig","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Riley Hospital for Children at Indiana University Health  Indianapolis Indiana USA"},{"name":"Department of Pediatric Hematology\/Oncology and Bone Marrow Transplantation Riley Hospital for Children  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1038\/bmt.2010.149"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1007\/s00246-017-1747-x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.3389\/fimmu.2021.605726"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1053\/j.ackd.2019.08.006"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1111\/petr.12062"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1097\/MPH.0000000000000974"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1182\/blood-2011-02-321315"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1016\/j.amjcard.2017.06.003"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1038\/sj.bmt.1705023"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.4103\/0971-4065.133024"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.2165\/00003495-199754060-00009"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1177\/0963689717727285"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1038\/bmt.2014.40"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1038\/bmt.2016.331"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1007\/s00467-017-3803-4"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.4103\/HEARTVIEWS.HEARTVIEWS_6_17"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1097\/TP.0000000000002836"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T06:15:39Z","timestamp":1724307339000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/petr.14672"],"URL":"https:\/\/doi.org\/10.1111\/petr.14672","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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