{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:30Z","timestamp":1787015970595,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to compare the efficacy and safety of basiliximab (BAS) versus a single dose of anti\u2010thymocyte globulin (r\u2010ATG) induction therapy in pediatric kidney transplant recipients (KTRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective comparative cohort study included all pediatric KTRs from May 2013 to April 2018 and followed up to 12\u2009months. In the first period, all recipients received BAS, while from May 2016, a single 3\u2009mg\/kg dose of r\u2010ATG was instituted. Maintenance therapy consisted of a calcineurin inhibitor plus prednisone plus azathioprine or mycophenolate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 227 patients were included (BAS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009113; r\u2010ATG,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009114). The main combination of immunosuppressive drugs was tacrolimus, prednisone, and azathioprine in both groups (87% vs. 88%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.718). Patients receiving r\u2010ATG showed superior survival\u2010free of the composite endpoint (acute rejection, graft loss, or death; 76% vs. 61%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003; HR 2.08, 1.29\u20133.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003) and lower incidence of biopsy\u2010proven acute rejection (10% vs. 21%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.015). There was no difference in the overall incidence of CMV infection (33% vs. 37%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.457), PTLD (1% vs. 3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.309), 30\u2010day hospital readmissions (24% vs. 23%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.847), and kidney function at 12\u2009months (86\u2009\u00b1\u200929 vs. 84\u2009\u00b1\u200930\u2009mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.614).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data suggest that induction therapy with a single 3\u2009mg\/kg dose of r\u2010ATG is associated with higher efficacy for preventing acute rejection and similar safety profile compared to BAS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.14713","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T01:24:17Z","timestamp":1711761857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of single\u2010dose anti\u2010thymocyte globulin versus basiliximab induction therapy in pediatric kidney transplant recipients: A retrospective comparative cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9529-7710","authenticated-orcid":false,"given":"Luciana de Fatima Porini","family":"Custodio","sequence":"first","affiliation":[{"name":"Hospital do Rim Funda\u00e7\u00e3o Oswaldo Ramos  S\u00e3o Paulo Brazil"},{"name":"Nephrology Division Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo 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