{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:45:36Z","timestamp":1791301536318,"version":"4.1.0"},"reference-count":98,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Intestinal failure, defined as the loss of gastrointestinal function to the point where nutrition cannot be maintained by enteral intake alone, presents numerous challenges in children, not least the timing of consideration of intestine transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the evolution of care of infants and children with intestinal failure including parenteral nutrition, intestine transplantation, and contemporary intestinal failure care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The review is based on the authors' experience supported by an in\u2010depth review of the published literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The history of parenteral nutrition, including out\u2010patient (home) administration, and intestine transplantation are reviewed along with the complications of intestinal failure that may become indications for consideration of intestine transplantation. Current management strategies for children with intestinal failure are discussed along with changes in need for intestine transplantation, recognizing the difficulty in generalizing recommendations due to the high level of heterogeneity of intestinal pathology and residual bowel anatomy and function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Advances in the medical and surgical care of children with intestinal failure have resulted in improved transplant\u2010free survival and a significant fall in demand for transplantation. Despite these improvements a number of children continue to fail rehabilitative care and require intestine transplantation as life\u2010saving therapy or when the burden on ongoing parenteral nutrition becomes too great to bear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.14756","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T06:12:13Z","timestamp":1713247933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["From intestinal failure to transplantation: Review on the current need for transplant indications under multidisciplinary transplant programs worldwide"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6555-9732","authenticated-orcid":false,"given":"Vikram K.","family":"Raghu","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Rumbo","sequence":"additional","affiliation":[{"name":"Unidad de Soporte Nutricional Rehabilitaci\u00f3n y Trasplante Intestinal Hospital Universitario Fundaci\u00f3n Favaloro  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5949-7363","authenticated-orcid":false,"given":"Simon P.","family":"Horslen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"e_1_2_21_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb12159.x"},{"key":"e_1_2_21_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.03.062"},{"key":"e_1_2_21_4_1","first-page":"517","article-title":"Uber die Resorption von Nahrungsmitteln vom Unterhautzellgewebe aus","volume":"19","author":"Menzel A","year":"1869","journal-title":"Wien Med Wochenschr"},{"key":"e_1_2_21_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607103027003225"},{"key":"e_1_2_21_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607181005003230"},{"issue":"1","key":"e_1_2_21_7_1","first-page":"134","article-title":"Long\u2010term total parenteral nutrition with growth, development, and positive nitrogen balance","volume":"64","author":"Dudrick SJ","year":"1968","journal-title":"Surgery"},{"key":"e_1_2_21_8_1","first-page":"260","article-title":"The artificial gut in hospital and home. 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