{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:13Z","timestamp":1753879393847,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Renal transplantation is currently the best treatment option for patients with end\u2010stage renal disease. However, the use of kidneys from donors under 6\u2009years of age as a possibility to increase the organ pool in pediatric recipients remains a controversial matter. We aimed to investigate whether donor age is associated to the long\u2010term functionality of the renal graft. Likewise, we analyzed the adaptation of the graft to the ascending functional requirements in the pediatric patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of the results obtained in pediatric recipients transplanted with grafts from donors between 3 and 6\u2009years of age, comparing them with those of grafts from donors older than 6\u2009years. Among the variables compared are cumulative graft survival, renal size, need for antiproteinuric therapy, GFR, incidence of rejection, pyelonephritis, renal failure and surgical or tumor complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 43 transplants were performed with donors aged 3\u20136\u2009years, and 42 transplants with donors older than 6\u2009years. Cumulative graft survival at 5\u2009years was 81% for the younger donor group compared to 98% for the older donor group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). At 8\u2009years, cumulative graft survival for donors &lt;6\u2009years was 74%. As for the mean estimated graft survival, it was 11.52\u2009years for the younger donor group and 14.51\u2009years for older donors. During follow\u2010up, the younger donor group presented greater renal enlargement and need for antiproteinuric therapy. The older donors group had a higher GFR during the first year of follow\u2010up, which then equalized in both groups. There were no statistically significant differences in the incidence of acute or chronic rejection, acute pyelonephritis, acute renal failure or surgical or tumor complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Renal transplants of grafts equal to or less than 6\u2009years old have good short\u2010term and acceptable long\u2010term results in pediatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14761","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T06:54:18Z","timestamp":1713336858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term outcome of pediatric renal transplantation with donors younger than 6\u2009years"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0908-3351","authenticated-orcid":false,"given":"Carla","family":"Ramirez\u2010Amoros","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery La Paz Children's University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"San\u00a0Basilio","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery La Paz Children's University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Amesty","sequence":"additional","affiliation":[{"name":"Department of Paediatric Urology La Paz Children's University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Paediatric Urology La Paz Children's University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Lobato","sequence":"additional","affiliation":[{"name":"Department of Paediatric Urology La Paz Children's University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlota","family":"Fernandez\u2010Camblor","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology La Paz Children's University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Lopez\u2010Pereira","sequence":"additional","affiliation":[{"name":"Department of Paediatric Urology La Paz Children's University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jose","family":"Martinez\u2010Urrutia","sequence":"additional","affiliation":[{"name":"Department of Paediatric Urology La Paz Children's University Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31829d672c"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13306"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13597"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl119"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01432.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-009-2350-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2019.03.015"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12049"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0210-4806(04)73034-X"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199208000-00008"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0350-9"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2637-y"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.265"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121296"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2006.02.010"},{"issue":"4","key":"e_1_2_11_18_1","first-page":"162","article-title":"Hould kidney grafts from donors less than 3\u2009years old be used?","volume":"3","author":"Lopez Gutierrez JC","year":"1990","journal-title":"Cir Pediatr"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2018.01.027"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2009.01260.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12924"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/317574"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.04.037"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T13:13:19Z","timestamp":1725628399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,16]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/petr.14761"],"URL":"https:\/\/doi.org\/10.1111\/petr.14761","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2024,4,16]]},"assertion":[{"value":"2023-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14761"}}