{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:23:29Z","timestamp":1773012209867,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK128835"],"award-info":[{"award-number":["R01DK128835"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["HHSH250\u20102019\u201000001C"],"award-info":[{"award-number":["HHSH250\u20102019\u201000001C"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["R18HS029292"],"award-info":[{"award-number":["R18HS029292"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM139776"],"award-info":[{"award-number":["T32 GM139776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tuberous sclerosis complex (TSC) is a disorder of the mammalian target of the rapamycin (mTOR) pathway associated with the development of multisystem tumors, including renal angiomyolipoma (AML). These renal tumors are benign by nature but locally invasive and carry a risk for the progression of chronic kidney disease (CKD) to end stage kidney disease (ESKD). The frequency of subsequent renal transplantation in this population is largely uncharacterized, although single\u2010center data suggests that 5%\u201315% of adult TSC patients are kidney transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study utilized United Network for Organ Sharing (UNOS) data. We included candidates waitlisted between 1987 and 2020 for a first kidney transplant with TSC\u2010associated kidney failure. We utilized descriptive statistics to characterize the frequency of first\u2010time kidney transplant waitlisting and transplantation among persons with TSC and the Fine\u2010Gray subdistribution hazard model to evaluate characteristics associated with progression from waitlist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 200 TSC\u2010associated kidney failure patients within the waitlist cohort. Of these, 12 were pediatric patients. Two\u2010thirds (<jats:italic>N<\/jats:italic>\u2009=\u2009134) of waitlisted persons were female. One hundred forty patients received a transplant with a median waitlist time of 2\u2009years. Younger age at waitlisting was associated with a greater probability of progressing to transplant (HR 0.98 [95% CI: 0.96\u20130.99]). 91.8% of kidney transplant recipients survived 1\u2010year post\u2010transplant with a functioning allograft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of patients with TSC who are waitlisted for a kidney transplant progress onto transplantation with excellent 1\u2010year post transplant patient and allograft survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14765","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:39:44Z","timestamp":1716446384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Kidney transplantation in patients with tuberous sclerosis complex"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6749-1471","authenticated-orcid":false,"given":"Amber M.","family":"Goedken","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Iowa College of Pharmacy  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1255-9691","authenticated-orcid":false,"given":"Wesam W.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Iowa College of Pharmacy  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-3859","authenticated-orcid":false,"given":"Lucas D. G.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Stead Family Department of Pediatrics University of Iowa Carver College of Medicine  Iowa City Iowa USA"},{"name":"Medical Scientist Training Program University of Iowa Carver College of Medicine  Iowa City Iowa USA"},{"name":"Department of Epidemiology University of Iowa College of Public Health  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-8132","authenticated-orcid":false,"given":"Lyndsay A.","family":"Harshman","sequence":"additional","affiliation":[{"name":"Stead Family Department of Pediatrics University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"National Institutes of Health.Tuberous sclerosis complex. Updated January 2023. 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