{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:54:07Z","timestamp":1788969247497,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["HHSH250\u20102019\u201000001C"],"award-info":[{"award-number":["HHSH250\u20102019\u201000001C"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Waitlist and posttransplant outcomes have been widely reported for pediatric liver transplantation. Yet, analyzing these metrics individually fails to provide a holistic perspective for patients and their families. Intent\u2010to\u2010treat (ITT) analysis fills this gap by studying the associations between waitlist outcomes, organ availability, and posttransplant outcomes. Our study aimed to construct a predictive index utilizing ITT analysis for pediatric liver transplant recipients (Pedi\u2010ITT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis utilizing de\u2010identified data provided by the United Network for Organ Sharing (UNOS) from March 1, 2002, to December 31, 2021. We analyzed data for 12\u2009926 pediatric recipients (age &lt;18). We conducted a univariate and multivariable logistic regression to find the significant predictive factors affecting ITT survival. A scoring index was constructed to stratify outcome risk on the basis of the significant factors identified by regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariable analysis found the following factors to be significantly associated with death on the waitlist or after transplant: gender, diagnosis, UNOS region, ascites, diabetes mellitus, age at the time of listing, serum sodium at the time of listing, total bilirubin at the time of listing, serum creatinine at the time of listing, INR at the time of listing, history of ventilator use, and history of re\u2010transplantation. Using receiver operator characteristic analysis, the Pedi\u2010ITT index had a <jats:italic>c<\/jats:italic>\u2010statistic of 0.79 (95% confidence interval [CI]: 0.76\u20130.82). The <jats:italic>c<\/jats:italic>\u2010statistics of the Model for End\u2010Stage Liver Disease\/Pediatric for End\u2010Stage Liver Disease and pediatric version of the Survival Outcomes Following Liver Transplantation score indices were 0.74 (CI: 0.71\u20130.76) and 0.69 (CI: 0.66\u20130.72), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Pedi\u2010ITT index provides an additional prognostic model with moderate predictive power to assess outcomes associated with pediatric liver transplantation. Further analysis should focus on increasing the predictive power of the index.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14816","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:49:30Z","timestamp":1719226170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Constructing an Intent\u2010to\u2010Treat Score Index to Predict Survival Outcomes in Pediatric Liver Transplant Recipients"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-0801","authenticated-orcid":false,"given":"Ashley","family":"Montgomery","sequence":"first","affiliation":[{"name":"Department of Student Affairs Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-7654","authenticated-orcid":false,"given":"Anna","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Student Affairs Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavana","family":"Kunisetty","sequence":"additional","affiliation":[{"name":"Department of Student Affairs Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2441-4342","authenticated-orcid":false,"given":"Spoorthi","family":"Kamepalli","sequence":"additional","affiliation":[{"name":"Department of Student Affairs Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-4353","authenticated-orcid":false,"given":"Jake","family":"Lynn","sequence":"additional","affiliation":[{"name":"Department of Student Affairs Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-514X","authenticated-orcid":false,"given":"Alexandra","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Student Affairs Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Goss","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplant, Michael E DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhu\u00a0Thao\u00a0Nguyen","family":"Galvan","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplant, Michael E DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-0598","authenticated-orcid":false,"given":"Abbas","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplant, Michael E DeBakey Department of Surgery Baylor College of Medicine  Houston Texas 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