{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:30:48Z","timestamp":1785335448041,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Varicella\u2010zoster virus (VZV) pretransplant immunization rates, exposures, and posttransplant disease are poorly characterized among pediatric solid organ transplant (SOT) recipients in the two\u2010dose varicella vaccine era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of the electronic health records among children &lt;18\u2009years old who received SOT from January 1, 2011 through December 31, 2021, was performed at a single center to assess for missed pretransplant varicella vaccination opportunities, characterize VZV exposures, and describe posttransplant disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 525 children, 444 were\u2009\u22656\u2009months old (m.o.) at SOT with a documented VZV vaccine status. Eighty\u2010five (19%) did not receive VZV Dose One; 30 out of 85 (35%) could have been immunized. Infants 6\u201311\u2009m.o. accounted for 14 out of 30 (47%) missed opportunities. Among children \u226512\u2009m.o. with documented Dose Two status (<jats:italic>n<\/jats:italic>\u2009=\u2009383), 72 had missed vaccination opportunities; 57 out of 72 (79%) were children 1\u20134\u2009years old. Most children had unclassifiable pre\u2010SOT serostatus as varicella serology was either not obtained\/documented (<jats:italic>n<\/jats:italic>\u2009=\u2009171) or the possibility of passive antibodies was not excluded (<jats:italic>n<\/jats:italic>\u2009=\u2009137). Of those with classified serology (<jats:italic>n<\/jats:italic>\u2009=\u2009188), 69 were seroimmune. Forty\u2010seven of 525 (9%) children had recorded VZV exposures; two developed varicella\u2014neither had documented pre\u2010SOT seroimmunity nor had received post\u2010exposure prophylaxis. Nine additional children had medically attended disease: four primary varicella and five zoster. Of the 11 cases, 10 had cutaneous lesions without invasive disease; one had multi\u2010dermatomal zoster with transaminitis. Seven (64%) received treatment exclusively outpatient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VZV exposure and disease still occur. Optimizing immunization among eligible candidates and ensuring patients have a defined VZV serostatus pretransplantation remain goals of care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14822","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T07:24:41Z","timestamp":1721978681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Varicella\u2010Zoster Virus Pretransplant Vaccination and Posttransplant Infections Among Pediatric Solid Organ Recipients in the Two\u2010Dose Varicella Era: A Single\u2010Center, Multi\u2010Organ Retrospective Study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0580-4716","authenticated-orcid":false,"given":"Gabriela\u00a0J.","family":"Espinoza\u2010Candelaria","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-6364","authenticated-orcid":false,"given":"Jonathan","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-6126","authenticated-orcid":false,"given":"Jorna","family":"Sojati","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9456-1770","authenticated-orcid":false,"given":"Judith\u00a0M.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-0544","authenticated-orcid":false,"given":"Marian\u00a0G.","family":"Michaels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-2894","authenticated-orcid":false,"given":"Michael","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Department of Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10110609"},{"key":"e_1_2_9_3_1","first-page":"831","volume-title":"Varicella Zoster Infections. 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