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However, the analysis of LTx registries in children provides much information about changes in the indication profiles in the recent years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The article provides a comprehensive review about the successes, hopes, and challenges related to changing indications for LTx in children based on the literature review and our own experience. Retrospective review of the indications for LTx at a tertiary referral pediatric hospital was also presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusions<\/jats:title><jats:p>In the context of the new therapies that have emerged, the need for LTx has decreased in patients with chronic hepatitis B and C infection and tyrosinemia type 1. In primary hyperoxaluria type 1, new RNAi\u2010based therapy has eliminated the requirement for LTx (both isolated or combined). There is a hope that introduction of ileal bile acid transporter (IBAT) blockers reduces the need for LTx in patients with Alagille syndrome or progressive familial intrahepatic cholestasis. The number of children qualified for LTx with urea cycle disorders (UCDs) as a prophylaxis of neurodevelopmental impairment is increasing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14825","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T07:23:05Z","timestamp":1720855385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modified by the Innovative Drugs and Strategies\u2014Pattern of Selected Indications for Pediatric Liver Transplantation"],"prefix":"10.1111","volume":"28","author":[{"given":"Irena","family":"Jankowska","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics The Children's Memorial Health Institute  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Socha","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics The Children's Memorial Health Institute  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Gliwicz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics The Children's Memorial Health Institute  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-8375","authenticated-orcid":false,"given":"Patryk","family":"Lipi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nutrition and Metabolic Diseases The Children's Memorial Health Institute  Warsaw Poland"},{"name":"Institute of Clinical Sciences Maria\u2010Sk\u0142odowska\u2010Curie Medical Academy  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-2838","authenticated-orcid":false,"given":"Dariusz","family":"Rokicki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nutrition and Metabolic Diseases The Children's Memorial Health Institute  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kalici\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Surgery and Organ Transplantation The Children's Memorial Health Institute  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Danielewska","sequence":"additional","affiliation":[{"name":"Department of Surgery and Organ Transplantation The Children's Memorial Health Institute  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryszard","family":"Grenda","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kidney Transplantation and Hypertension The Children's Memorial Health Institute  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-057424"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.04.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25433"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-020-04817-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13614"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25478"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(05)70142-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010213"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v13.i10.1351"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1103757"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14553"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12694"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000925"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1627456"},{"key":"e_1_2_7_16_1","unstructured":"https:\/\/apps.who.int\/iris\/handle\/10665\/246177. 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