{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:30:46Z","timestamp":1785335446426,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Administration of live vaccines following liver transplant (LT) has historically not been recommended due to concerns regarding risk of vaccine\u2010attenuated disease. However, there is evidence suggesting that in select transplant recipients live vaccinations can be administered safely. Studies in other regions have indicated that despite this evidence many clinicians remain hesitant to administer live vaccinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A REDCap survey was distributed to gastroenterologists, pediatricians, and infectious diseases physicians at pediatric centers across Australia and New Zealand via email between September and November 2023. The survey included a series of questions regarding live vaccine and varicella postexposure prophylaxis (PEP) practices in pediatric LT recipients and barriers to live vaccine administration in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a total of 16 responses to the survey, from 10 different pediatric centers, including 10\/11 pediatric gastroenterology centers and all four pediatric LT centers in the region. Only 31% (5\/16) of respondents (from 3\/10 different centers) offer live vaccines. The main barrier to live vaccine administration was clinician reluctance and the main reason for not offering live vaccines was insufficient safety data.<\/jats:p><jats:p>Sixty\u2010nine percent (11\/16) of respondents take vaccination status and\/or serology into account when deciding whether to offer varicella PEP to this cohort. Respondents universally offer varicella zoster immunoglobulin as PEP, though 31% (5\/16) also offer antiviral medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many clinicians in our region remain hesitant to provide live vaccines to pediatric LT recipients, with concerns regarding insufficient safety data. Updated local guidelines may help to address this.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14833","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T04:48:40Z","timestamp":1721710120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Live Vaccine and Varicella Postexposure Prophylaxis in Pediatric Liver Transplant Recipients: A Survey of Practice in Australia and New Zealand"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9722-2204","authenticated-orcid":false,"given":"Emily","family":"Bonett","sequence":"first","affiliation":[{"name":"Queensland Specialist Immunisation Service Children's Health Queensland  South Brisbane Queensland Australia"},{"name":"Department of Paediatrics Bendigo Health Care Group  Bendigo Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-7076","authenticated-orcid":false,"given":"Rebecca","family":"Doyle","sequence":"additional","affiliation":[{"name":"Queensland Specialist Immunisation Service Children's Health Queensland  South Brisbane Queensland Australia"},{"name":"School of Nursing, Midwifery and Social Work University of Queensland  St Lucia Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-7385","authenticated-orcid":false,"given":"Amin","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Paediatric Gastroenterology Starship Child Health  Auckland New Zealand"},{"name":"Department of Paediatrics University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7727-4443","authenticated-orcid":false,"given":"Sophie\u00a0C.\u00a0H.","family":"Wen","sequence":"additional","affiliation":[{"name":"Queensland Specialist Immunisation Service Children's Health Queensland  South Brisbane Queensland Australia"},{"name":"University of Queensland Centre for Clinical Research  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit816"},{"key":"e_1_2_10_3_1","unstructured":"Australian Government Department of Health and Aged Care Vaccination for People Who Are Immunocompromised. The Australian Immunisation Handbook2023 accessed January 31 2024 https:\/\/immunisationhandbook.health.gov.au\/contents\/vaccination\u2010for\u2010special\u2010risk\u2010groups\/vaccination\u2010for\u2010people\u2010who\u2010are\u2010immunocompromised#solid\u2010organ\u2010transplant\u2010recipients."},{"key":"e_1_2_10_4_1","unstructured":"Ministry of Health New Zealand Immunisation of Special Groups accessed January 31 2024 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