{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:26Z","timestamp":1753879346442,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nodal marginal zone lymphoma (NMZL) is a rare form of non\u2010Hodgkin lymphoma (NHL), accounting for around 2% of all NHL in pediatrics and adults. It is considered the least common subtype of marginal zone lymphoma, which is rarely seen in pediatrics and is usually viewed as a mild disease. In adults, its presentation varies from mild to aggressive disease with multiple lymph node enlargement and systemic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>Here, we report an interesting case of a 31\u2010month\u2010old boy who developed refractory EBV\u2010positive NMZL with extensive disease. The tumor did not respond well to conventional chemotherapy and Rituximab. Therefore, we manage the disease with second\u2010line chemotherapy, including bortezomib, followed by an allogeneic hematopoietic stem cell transplant (HSCT) with an excellent outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Very few cases have been reported for aggressive NMZL children. The tumor was refractory to first line chemotherapy. However, the successful outcome was achieved by allogeneic stem cell transplant with myeloablative conditioning chemotherapy. The significance of this particular case is that this is the first reported case from pediatrics for refractory NMZL, which responded well to allogeneic stem cell transplant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14835","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T03:06:19Z","timestamp":1724295979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Refractory Nodal Marginal Zone Lymphoma in a Child, Successfully Cured by Allogeneic Stem Cell Transplant: A Case Report"],"prefix":"10.1111","volume":"28","author":[{"given":"Shahbaz","family":"Memon","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology and Bone Marrow Transplant Ministry of National Guard and Health Affairs  Riyadh Saudi Arabia"},{"name":"Department of King Histopathology King Saud bin Abdulaziz University for Health Sciences  Riyadh Saudi 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Allergy Ministry of National Guard and Health Affairs  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-0796","authenticated-orcid":false,"given":"Mohammad","family":"Essa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology and Bone Marrow Transplant Ministry of National Guard and Health Affairs  Riyadh Saudi Arabia"},{"name":"Department of King Histopathology King Saud bin Abdulaziz University for Health Sciences  Riyadh Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Riyadh Saudi 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