{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:44:08Z","timestamp":1753879448820,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Haploidentical hematopoietic stem cell transplant (HSCT) is a curative treatment especially for countries where bone marrow registries are nonexistent. We present our experience with haploidentical HSCT in pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective data collected and analyzed for patients \u226418\u2009years, from January 2017 to December 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort consisted of 20 patients with median age at transplant of 61.5 (IQR: 124) months. Fourteen (70%) were malignant and 6 (30%) were benign diseases. Donors were father in majority (9\/20; 45%). Stem cell source was peripheral blood 8, marrow 8, and combined 4. c\u2010specific antibodies were positive in 6 (30%). Median CD34 cell dose infused: 9.35\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\/kg. Median engraftment time: 15 (IQR: 17) days. Acute and chronic graft\u2010versus\u2010host disease (GVHD) occurred in 12\/20 (60%) and 5\/20 (25%), respectively. Complications included infection\/sepsis (14\/20; 70%), cytomegalovirus reactivation (14\/20; 70%), sinusoidal obstruction syndrome (1\/20; 5%), primary graft failure (PGF) (6\/20; 30%), and secondary graft failure (4\/20; 20%). PGF was more common in benign conditions (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and less prevalent in cases with aGVHD (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). aGVHD was more common in malignant conditions (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). Overall survival (OS), relapse\u2010free survival (RFS), and treatment\u2010related mortality (TRM) were 40%, 50%, and 35%, respectively. Median time of survival and relapse were 8 (IQR: 15) and 9 (IQR: 13) months, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OS was comparable to that of other low\u2013middle\u2010income countries. GVHD was a major challenge, along with sepsis and CMV infection. Half of the leukemias relapsed. Graft failure was a major concern in nonmalignant diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14842","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T11:35:37Z","timestamp":1724067337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Initiation of Haploidentical Stem Cell Transplantation With Post\u2010Transplant Cyclophosphamide in Children: A Low\u2013Middle\u2010Income Country Institutional Experience"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1805-1331","authenticated-orcid":false,"given":"Syed\u00a0Ibrahim","family":"Bukhari","sequence":"first","affiliation":[{"name":"Department of Oncology Aga Khan University  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javeria","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Surgery Aga Khan University  Karachi 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