{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:30Z","timestamp":1753879350494,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although adult transplant centers are successfully transplanting organs from hepatitis C virus (HCV)\u2010infected donors with detectable viral load by nucleic acid testing (NAT+) into HCV\u2010negative recipients, this practice has not yet been adopted widely by the pediatric heart transplant community.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present a case series of four patients who received heart transplants from HCV NAT+ donors at a pediatric transplant center, including two pediatric patients\u2009&lt;\u200918\u2009years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All recipients tolerated a 12\u2010week course of glecaprevir\/pibrentasvir and achieved a sustained virologic response with no HCV or liver complications with over 1\u2009year of follow\u2010up (range 1.4\u20132.5\u2009years). All four have had good post\u2010heart transplant outcomes with normal graft function and good functional status without rejection or cardiac allograft vasculopathy at time of last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case series details the successful multidisciplinary implementation of a protocol to accept cardiac allografts from HCV NAT+ donors for transplantation into HCV negative recipients at our pediatric transplant center. With the limited donor pool in pediatrics and the morbidity associated with prolonged durations on the transplant waitlist, pediatric centers should consider utilizing organs from HCV NAT+ donors to broaden the donor pool. Future work should evaluate other organs beyond heart and optimal timing and duration of direct acting antiviral therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14879","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T02:40:08Z","timestamp":1730083208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilization of Hepatitis C Virus\u2010Infected Donor Hearts in Two Children and Two Young Adults: Initial Experience at a Pediatric Transplant Center"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2626-316X","authenticated-orcid":false,"given":"Lauren\u00a0E.","family":"Kushner","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics Stanford University School of Medicine  California 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