{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:22Z","timestamp":1753879402578,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intestinal complications (IC) represent serious adverse events after liver transplantation (LT), however limited research has been conducted in pediatric cohorts. This study aims to describe IC after pediatric LT and to identify associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of 153 patients having undergone LT, aged 0\u201318\u2009years, treated in the Swiss Pediatric Liver Center in Geneva. Pre\u2010, per\u2010 and postoperative data were analyzed. IC were defined as pathologies or lesions directly associated with LT and attributable to the surgical procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>16\/153 (11%) patients developed IC: 10\/16 mechanical obstructions, 4\/16 intestinal perforations and 2\/16 sub\u2010mesocolic abscesses. IC patients had a significantly lower Body Mass Index (BMI) (15.5 vs. 16.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.019). Children with IC had significantly higher incidence of previous Kasai hepatoportoenterostomy associated with Ladd procedure (13% vs. 2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.055), a history of intraoperative iatrogenic intestinal perforation(s) (31% vs. 5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and prolonged LT surgery duration (536 vs. 415\u2009min, <jats:italic>p<\/jats:italic>\u2009=\u20090.007). Significantly more children with IC had received basiliximab (69% vs. 40%, <jats:italic>p<\/jats:italic>\u2009=\u20090.048). Patients with IC exhibited a higher incidence of post\u2010LT sub\u2010occlusions (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and an increased requirement for post\u2010LT parenteral nutrition (<jats:italic>p<\/jats:italic>\u2009=\u20090.027). Additionally, IC patients underwent significantly more reoperations (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One in 10 children post\u2010LT experiences IC, which are associated with significant morbidity. Pre\u2010LT nutritional status appears as an associated factor with IC, along with the necessity for adhesiolysis during LT, often leading to prolonged operative time. These associated factors should alert medical teams to promote early IC diagnosis in patients after LT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14888","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T11:38:34Z","timestamp":1731325114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective Cohort Study of Associated Factors for Intestinal Complications in Pediatric Liver Transplantation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9322-4568","authenticated-orcid":false,"given":"Sindy","family":"Pires","sequence":"first","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie A.","family":"McLin","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University Hospitals of Geneva  Geneva Switzerland"},{"name":"Pediatric Gastroenterology, Hepatology and Nutrition Unit, Division of Pediatric Specialties, Department of Pediatrics, Gynecology and Obstetrics University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Rock","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University Hospitals of Geneva  Geneva Switzerland"},{"name":"Pediatric Gastroenterology, Hepatology and Nutrition Unit, Division of Pediatric Specialties, Department of Pediatrics, Gynecology and Obstetrics University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana\u2010Maria","family":"Calinescu","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University Hospitals of Geneva  Geneva Switzerland"},{"name":"Division of Pediatric and Adolescent Surgery, Unit of Pediatric Surgery, University Center of Pediatric Surgery of Western Switzerland, Department of Pediatrics, Gynecology and Obstetrics University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara E.","family":"Wildhaber","sequence":"additional","affiliation":[{"name":"Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics University Hospitals of Geneva  Geneva Switzerland"},{"name":"Division of Pediatric and Adolescent Surgery, Unit of Pediatric Surgery, University Center of Pediatric Surgery of Western Switzerland, Department of Pediatrics, Gynecology and Obstetrics University Hospitals of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2018.06.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2020.10.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2722-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13415"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13911"},{"issue":"2","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.54847\/cp.2023.02.14","article-title":"Intestinal Perforation After Pediatric Liver Transplantation: Risk Factors and Management","volume":"36","author":"Barila P.","year":"2023","journal-title":"Cirug\u00eda 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