{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:19:23Z","timestamp":1772608763861,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory bowel diseases are complex chronic disorders with a relapsing\u2013remitting course that affect the gut due to dysregulated immune response. The incidence of these disorders is increasing globally along with an increase in the incidence in pediatric population. Very early onset inflammatory bowel diseases are seen in children with age less than 6\u2009years, where monogenic causes predominate. With the advent of next\u2010generation sequencing methods, these disorders are being diagnosed more. Interleukin\u201010 receptor mutation\u2010associated inflammatory bowel diseases is one such monogenic disorder where immunosuppression shows poor response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report the case of an 8\u2010month\u2010old child of Indian origin who presented with severe enterocolitis and rectovaginal fistulas. She was evaluated on lines of a very early onset inflammatory bowel disease. She was found to have a mutation in the interleukin\u201010 receptor causing severe enterocolitis. She underwent a diversion colostomy. She was admitted at 25\u2009months of age for the hematopoietic\u2010stem\u2010cell\u2010transplant (HSCT). The conditioning regimen used consisted of busulfan, fludarabine, and anti\u2010thymocyte\u2010globulin (ATG). The child received a 10\/10 human leukocyte antigen (HLA) matched from a matched\u2010unrelated adult female donor with bone marrow stem cell product at a dose of 5.6 million CD34+\u2009cells per kg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>She was treated successfully by a matched unrelated donor HSCT. At present, she is 2\u2009years and 4 months posttransplant and is cured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early recognition and prompt genetic testing can help in diagnosing and establishing the cause of a very early onset inflammatory bowel disease. Very early onset inflammatory bowel disease caused due to interleukin\u201010 receptor mutations can be cured by HSCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14891","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T08:13:44Z","timestamp":1731572024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Matched Unrelated Donor Hematopoietic Stem Cell Transplant as Successful Curative Therapy for IL10RB Mutation\u2010Associated Very Early Onset IBD"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2175-697X","authenticated-orcid":false,"given":"Rohan","family":"Grotra","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9779-2408","authenticated-orcid":false,"given":"Padma Sagarika","family":"Karri","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Malik","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-8944","authenticated-orcid":false,"given":"Aditya Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdish Prasad","family":"Meena","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachna","family":"Seth","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Pediatrics All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-018-2778-x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001859"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.025"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2018.08.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz259"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907206"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i43.12296"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elt028"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-43492-5_1"},{"key":"e_1_2_8_11_1","first-page":"6","article-title":"Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis","volume":"2","author":"Loddo I.","year":"2015","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i5.1211"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.07.023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0909225"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.14740\/gr740w"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.045"},{"key":"e_1_2_8_18_1","article-title":"Temporary Faecal Diversion for Refractory Perianal and\/or Distal Colonic Crohn's Disease in the Biologic Era: An Updated Systematic Review With Meta\u2010Analysis","volume":"14","author":"Jew M.","year":"2023","journal-title":"Journal of Crohn's and 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