{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:21:57Z","timestamp":1787062917598,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood group incompatibility previously represented an obstacle to living related donor (LRD) options; desensitization modalities have expanded LRD options. ABO\u2010incompatible kidney transplants have been successful in adults and pediatric liver transplants, but to date not yet in pediatric kidney transplants in South Africa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>\n                      Patient X is a 5\u2009year old male with end\u2010stage kidney failure due to Posterior Urethral Valves, requiring peritoneal dialysis pre\u2010transplant. His sister was the only suitable LRD. The recipient was blood group A+; donor was blood group B+; HLA match was 5\/10, nil HLA donor specific antibodies and negative CDC and Flow crossmatches. The recipients' anti\u2010B titer pre\u2010transplant was a maximum of 1:8. A pre\u2010emptive desensitization dose of Rituximab (375\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) was administered 4\u2009weeks before transplant. The anti\u2010B titer decreased to 1:2 following the Rituximab (CD19% of 0%). Post\u2010transplant, the Anti\u2010B titers were monitored for the first 10\u2009days, with a maximum titer of 1:8 (immunoadsorbtion therapy available if &gt;\u20091:16, or if associated graft dysfunction). Immunosuppressant protocol consisted of Basiliximab, Tacrolimus, Azathioprine, and Prednisone. Post\u2010transplant, the creatinine improved to 60\u201370 \u03bcmol\/L at Week 1. 7\u2009weeks post\u2010transplant, serum creatinine increased &gt;\u200910% with an antibody titer of 1:2. Kidney biopsy showed CNI\u2010related toxicity; renal function improved with reduction in Tacrolimus doses. Kidney function remains stable\u00a01\u2010year post\u2010transplant with nil episodes of rejection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first ABO\u2010incompatible kidney transplant in a pediatric patient in South Africa and represents an important step in expanding the pool of potential living related donors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70000","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T07:39:40Z","timestamp":1734421180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["First\n                    <scp>ABO<\/scp>\n                    \u2010Incompatible Pediatric Kidney Transplant in South Africa\u2014A Case Report"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-9978","authenticated-orcid":false,"given":"Ashton","family":"Coetzee","sequence":"first","affiliation":[{"name":"University of Cape Town  Cape Town South Africa"},{"name":"Red Cross Children's War Memorial Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-4456","authenticated-orcid":false,"given":"Peter","family":"Nourse","sequence":"additional","affiliation":[{"name":"University of Cape Town  Cape Town South Africa"},{"name":"Red Cross Children's War Memorial Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Abdo","sequence":"additional","affiliation":[{"name":"University of Cape Town  Cape Town South Africa"},{"name":"Red Cross Children's War Memorial Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taryn","family":"Pienaar","sequence":"additional","affiliation":[{"name":"University of Cape Town  Cape Town South Africa"},{"name":"Red Cross Children's War Memorial Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thozama","family":"Siyothula","sequence":"additional","affiliation":[{"name":"University of Cape Town  Cape Town South Africa"},{"name":"Red Cross Children's War Memorial Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8840-9032","authenticated-orcid":false,"given":"Tinus","family":"Du Toit","sequence":"additional","affiliation":[{"name":"University of Cape Town  Cape Town South Africa"},{"name":"Groote Schuur Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-3611","authenticated-orcid":false,"given":"Dave","family":"Thomson","sequence":"additional","affiliation":[{"name":"University of Cape Town  Cape Town South Africa"},{"name":"Groote Schuur Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-1477","authenticated-orcid":false,"given":"Zunaid A.","family":"Barday","sequence":"additional","affiliation":[{"name":"University of Cape Town  Cape Town South Africa"},{"name":"Groote Schuur Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongiswa","family":"Ndamase","sequence":"additional","affiliation":[{"name":"Red Cross Children's War Memorial Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-4785","authenticated-orcid":false,"given":"Mignon I.","family":"McCulloch","sequence":"additional","affiliation":[{"name":"University of Cape Town  Cape Town South Africa"},{"name":"Red Cross Children's War Memorial Hospital  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13597"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13418"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)32091\u20109"},{"key":"e_1_2_8_5_1","first-page":"79","article-title":"ABO\u2010Incompatible Kidney Transplantation Using Immunoadsorption Columns: First Experiences in South Africa","volume":"114","author":"Barday Z.","year":"2024","journal-title":"SAMJ"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00234"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002259"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010022\u201005583\u20105"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010019\u201004376\u20107"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13138"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T07:47:06Z","timestamp":1737964026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/petr.70000"],"URL":"https:\/\/doi.org\/10.1111\/petr.70000","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,17]]},"assertion":[{"value":"2024-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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