{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:25:17Z","timestamp":1757456717216,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Biliary atresia (BA) remains a prevalent indication for pediatric liver transplantation (LT). We investigated the prognostic value of the serum matrix metalloproteinases 7 (MMP\u20107) and alkaline phosphatase (ALP) level combined detection for BA children post\u2010Kasai surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively enrolled 85 BA children who underwent Kasai surgery. They were divided into the native liver (NL) and LT groups based on their three\u2010year postoperative prognosis. Serum MMP\u20107 and ALP levels were measured by ELISA. The relationship of intraoperative serum MMP\u20107 and ALP levels with preoperative gamma\u2010glutamyltransferase (GGT), and their impact on the risk of postoperative LT were analyzed by Pearson's correlation coefficient and Kaplan\u2013Meier curves. The independent risk factors (IRFs) for postoperative LT and the predictive value of the serum MMP\u20107 and ALP level combined detection for postoperative LT in BA children were analyzed by Cox regression analysis and receiver operating characteristic (ROC) curves. MedCalc software compared the areas under the ROC curves (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences were observed between the two groups in BA classification, postoperative jaundice clearance rate, and cholangitis occurrence. Intraoperative serum MMP\u20107 and ALP levels were higher in the LT group and positively correlated with preoperative GGT. High MMP\u20107 and ALP levels were IRFs for postoperative LT, while significant jaundice clearance was a protective factor. Combined MMP\u20107 and ALP detection (0.926 AUC, 91.30% sensitivity, 87.18% specificity) significantly improved the prediction for LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High MMP\u20107 and ALP levels are IRFs for post\u2010Kasai surgery LT in BA children, with their combination providing superior predictive value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.70004","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T10:11:02Z","timestamp":1736331062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of Combined Detection of <scp>MMP<\/scp>\u20107 and <scp>ALP<\/scp> Levels in Children With Biliary Atresia Post\u2010Kasai Surgery"],"prefix":"10.1111","volume":"29","author":[{"given":"Qingzhi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neonatal Surgery Anhui Children's Hospital  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoxiang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neonatal Surgery Anhui Children's Hospital  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0339-8189","authenticated-orcid":false,"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neonatal Surgery Anhui Children's Hospital  Hefei 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