{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:33:54Z","timestamp":1789475634994,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,2]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Disseminated mycobacterium poses a significant risk for patients with NEMO deficiency. Hematopoietic stem cell transplant (HSCT) corrects the NEMO defect in hematopoietic cells thus treating the immunodeficiency.<\/jats:p><\/jats:sec>Methods<\/jats:title>We present a patient with NEMO deficiency who successfully underwent HSCT despite a disseminated Mycobacterium szulgai<\/jats:italic><\/jats:styled-content> infection.<\/jats:p><\/jats:sec>Results<\/jats:title>Despite successful engraftment and resolution of the mycobacterium infection, he developed inflammatory disease leading to his death.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>HSCT does not cure all aspects of the NEMO protein defect and posttransplant inflammatory diseases involving nonhematopoietic cell types may manifest clinically.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.70020","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T10:10:16Z","timestamp":1736331016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Patient With NEMO<\/scp> Deficiency, Disseminated M. szulgai<\/i>,<\/scp> and Post\u2010HSCT<\/scp> Inflammatory Disease"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-829X","authenticated-orcid":false,"given":"Ayelet","family":"Rosenthal","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"},{"name":"Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-3734","authenticated-orcid":false,"given":"Alka","family":"Goyal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics Stanford University School of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-258X","authenticated-orcid":false,"given":"Sharon F.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics Stanford University School of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Pediatrics Stanford University School of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5700-6188","authenticated-orcid":false,"given":"Ami","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics Stanford University School of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-771600"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00001-11"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.032"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2014.15.5.651"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/529443"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45258"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.04.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.03.514"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T12:47:25Z","timestamp":1737982045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/petr.70020"],"URL":"https:\/\/doi.org\/10.1111\/petr.70020","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]},"assertion":[{"value":"2024-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70020"}}