{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:19:12Z","timestamp":1770909552318,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010liver transplantation\u2013Burkitt lymphoma (PLT\u2010BL) is an aggressive and life\u2010threatening complication after pediatric liver transplantation. The research on the disease characteristics, treatment, and prognosis of pediatric PLT\u2010BL is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, observational study was performed to analyze the disease characteristics, treatment, and outcomes in 12 pediatric liver transplant (LT) recipients diagnosed with PLT\u2010BL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The medium time from liver transplantation to diagnosis was 32.71\u2009months (range, 25.78\u201337.85\u2009months). All patients (100%) tested positive for EBV viremia at diagnosis. Abdomen and peripheral lymph nodes were the most frequently involved sites (11 [91.66%] and 10 [83.33%], respectively). Three pediatric patients were diagnosed as relapsed or refractory PLT\u2010BL and treated with chimeric antigen receptor (CAR) T\u2010cell therapy, and two of them achieved complete remission (CR). Nine patients were alive with CR at the last follow\u2010up. Three deaths were attributed to progression and tumor lysis syndrome, characterized by significantly elevated lactate dehydrogenase (LDH) levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.027), more advanced tumor stages (<jats:italic>p<\/jats:italic>\u2009=\u20090.045), and an increased number of involved sites (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). With a median follow\u2010up of 2.7\u2009years after diagnosis, the event\u2010free survival (EFS) and overall survival (OS) rates for PLT\u2010BL patients were 66.7% and 74.1%, respectively. In four patients, immunosuppression was successfully withdrawn and they maintained tolerance status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated LDH levels, more advanced tumor stages, and increased number of involved sites are potentially associated with poor outcome. Immunosuppression withdrawal is a safe and feasible approach for PLT\u2010BL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.70027","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T02:49:07Z","timestamp":1738896547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post\u2010Liver Transplantation\u2013Burkitt Lymphoma in Children: A Single\u2010Center Study of Clinical Characteristics, Treatment, and Outcomes"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7100-7930","authenticated-orcid":false,"given":"Tianran","family":"Chen","sequence":"first","affiliation":[{"name":"First Central Clinical School Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation, Organ Transplantation Center Tianjin First Central Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruofan","family":"Wang","sequence":"additional","affiliation":[{"name":"First Central Clinical School Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation, Organ Transplantation Center Tianjin First Central Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1318-9917","authenticated-orcid":false,"given":"Chao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation, Organ Transplantation Center Tianjin First Central Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3699-2913","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation, Organ Transplantation Center Tianjin First Central Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation, Organ Transplantation Center Tianjin First Central Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinzhe","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation, Organ Transplantation Center Tianjin First Central Hospital  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-3516","authenticated-orcid":false,"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation, Organ Transplantation Center Tianjin First Central Hospital  Tianjin China"},{"name":"Tianjin Key Laboratory of Organ Transplantation  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.02.019"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022019543"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23385"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.294"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.26034"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.4961"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0377"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70300-X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18498"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.282297"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-022-03404-6"},{"issue":"3","key":"e_1_2_11_15_1","first-page":"332","article-title":"Classification, Staging and End Results of Treatment of Childhood Non\u2010Hodgkin's Lymphomas: Dissimilarities From Lymphomas in Adults","volume":"7","author":"Murphy S. 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