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BA is the leading indication for pediatric liver transplantation, while HB is the most common childhood liver cancer. Despite improved outcomes through advanced surgical techniques and novel immunosuppression, pediatric liver transplantation (pLT) is complicated by post\u2010transplant infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was performed of pLT recipients at Cincinnati Children's Hospital Medical Center (CCHMC) and stratified patients by underlying disease to assess impact on post\u2010transplant infectious events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BA patients were youngest at pLT (12.5\u2009months; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to other disease cohorts (HB 30.8, other 43.7). All HB patients received organs from deceased donors. In the year following pLT, 93% of the patients experienced at least one infectious event (IE). HB patients had the highest mean number of IE across disease groups (5.5\u2009IE\/patient vs. BA 4.5, other 4.0; <jats:italic>p<\/jats:italic>\u2009=\u20090.055), with significantly more patients with fever and neutropenia (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and EBV infections (<jats:italic>p<\/jats:italic>\u2009=\u20090.012). HB patients were more likely to develop IE earlier after pLT than non\u2010HB groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.013), especially <jats:italic>Clostridioides difficile<\/jats:italic> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and fever and neutropenia (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Despite having variable IE experiences, 1\u2010and\u20105\u2010year survival across disease groups were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IE were frequently observed in HB patients after pLT, possibly related to pre\u2010and\u2010postoperative chemotherapy and associated neutropenia. Underlying disease may help inform targeted infection\u2010related patient management following pLT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.70035","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T11:30:21Z","timestamp":1737977421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Hepatoblastoma on Infectious Complications Following Pediatric Liver Transplantation"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-7484","authenticated-orcid":false,"given":"Ashton D.","family":"Hall","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hope A.","family":"Hendricks","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Duke 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M.","family":"Tiao","sequence":"additional","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy E.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Otto","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-6513","authenticated-orcid":false,"given":"Grant C.","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Division of 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