{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:22:27Z","timestamp":1777983747431,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Budd\u2010Chiari syndrome (BCS) presents with various degrees of liver damage, and the choice of treatment depends on the type and extent of hepatic injury. Liver transplantation (LT) is considered as the final treatment option when other interventions are not feasible and when the liver injury is irreversible. We report a case of a pediatric patient with BCS who underwent liver transplantation from a living donor in the context of thrombophilic disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 14\u2010month\u2010old girl was admitted to the hospital with ascites. She was malnourished, and an abdominal CT scan confirmed significant ascites with no visualization of the hepatic veins and retrohepatic inferior vena cava (IVC). A liver biopsy revealed fibrosis, necrosis, and parenchymal hemorrhage. Patient's portal hypertension was managed with prophylactic beta\u2010blocker Propranolol and endoscopic esophageal variceal ligation. However, she was hospitalized four times due to gastrointestinal bleeding from ruptured esophageal varices. Protein C deficiency was found as probable etiology of BCS. The patient underwent liver transplantation at 3\u2009years and 8\u2009months old with a liver from a parental living donor. The surgery and postoperative course were uneventful, and the patient was discharged 25\u2009days after the transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Discussion<\/jats:title><jats:p>Hypercoagulability is often the underlying cause of BCS. Maintaining anticoagulation\/thrombophilic balance postoperatively contributed to the successful liver transplantation in this pediatric patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver transplantation is a safe and effective treatment for pediatric patients with BCS who meet the criteria for the procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.70038","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T02:28:30Z","timestamp":1738636110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Liver Transplantation for Children With Budd\u2010Chiari Syndrome: A Case Report From Vietnam and Literature Review"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-4217","authenticated-orcid":false,"given":"Thanh Tri","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Diseases and Liver Transplant Children's Hospital 2  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0613-7622","authenticated-orcid":false,"given":"Thi Yen Nhi","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Diseases and Liver Transplant Children's Hospital 2  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Van Khanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Diseases and Liver Transplant Children's Hospital 2  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen An Thuan","family":"Luu","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Diseases and Liver Transplant Children's Hospital 2  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trong Thien","family":"Than","sequence":"additional","affiliation":[{"name":"Lam Dong Children's Hospital  Dalat Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai Trung","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Diseases and Liver Transplant Children's Hospital 2  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-6230","authenticated-orcid":false,"given":"Phi Duy","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Diseases and Liver Transplant Children's Hospital 2  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Pirotte","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Reding","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery and Transplantation Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13132256"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2018.10.014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180441"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2021.09.007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v8.i16.691"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2024.109294"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14441"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2012.01683.x"},{"issue":"10","key":"e_1_2_6_10_1","first-page":"1783","article-title":"The Budd\u2010Chiari Syndrome in a Child: A Case Report and Review of the Literature","volume":"6","author":"MiSra V.","year":"2012","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181938b10"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-3-200908040-00004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v15.i11.1174"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000583"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181aecb63"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000144"},{"issue":"63","key":"e_1_2_6_17_1","first-page":"662","article-title":"Experience With Mesocaval Shunt With Autologous Jugular Vein Interposition in Patients With Budd\u2010Chiari Syndrome","volume":"52","author":"Ilkgul 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