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The contributions of pharmacotherapeutic aspects to this practice have been of fundamental importance, even in low\u2010 and middle\u2010income countries (LMIC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a quasi\u2010systematic review of the PubMed and Google Scholar databases from inception to July 2024 using Medical Subject Headings and keywords relevant to Therapeutic Drug Monitoring (TDM) and Model\u2010Based Precision Dosing (MIPD). The quality of the articles and data collected were appraised using the appropriate critical appraisal tools and was synthesized qualitatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TDM and the analyses and interpretations associated with pharmacometric aspects, specifically clinical pharmacokinetics, have led to the use of modern strategies such as MIPD. These strategies allow for individually adjusted drug dosages to be optimized, making them more effective and safer for many immunosuppressants, antibiotics, antivirals, antifungals, antiepileptics, antineoplastics, and antiarrhythmics, among others. Several points of interest associated with improving the implementation and practice of TDM\u2010MIPD, particularly challenging in LMICs, include the availability and adequate management of economic resources (such as software and laboratory supplies), the development of collaborative work with other institutions (including foreign ones), the possibility of consolidating independent management not depending on other clinical services, the need to train and maintain highly skilled professional staff for clinical and research purposes, and the establishment and maintenance of specialized educational programs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Throughout the world, but especially in LMICs, there is a need to intensify strategies that allow for the more widespread application of TDM\u2010MIPD to improve pharmacotherapeutic care for this highly vulnerable patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.70074","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T12:46:10Z","timestamp":1743770770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Precision Dosing, Therapeutic Drug Monitoring, and Clinical Pharmacokinetics in Pediatric Kidney Transplant Patients: Principles and Practice With Emphasis on Low\u2010 and Middle\u2010Income Countries"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9747-4960","authenticated-orcid":false,"given":"Paulo","family":"Caceres Guido","sequence":"first","affiliation":[{"name":"Pharmacokinetics and Clinical Pharmacology Research Unit, Pharmacy Area Hospital de Pediatria J.P Garrahan  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5644-7771","authenticated-orcid":false,"given":"Guillermo Federico","family":"Taboada","sequence":"additional","affiliation":[{"name":"Pharmacokinetics and Clinical Pharmacology Research Unit, Pharmacy Area Hospital de Pediatria J.P Garrahan  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-2066","authenticated-orcid":false,"given":"Marta Lidia","family":"Monteverde","sequence":"additional","affiliation":[{"name":"Nephrology Department, Renal Transplant Unit Hospital de Pediatria J.P Garrahan  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"The Transplantation Society \u201cPractical Protocols for Living Donor Kidney Transplantation \u201d(2010) https:\/\/www.tts.org\/images\/stories\/practical_protocols\/Practical_Protocols_ENG.PDF."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2022.151194"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004186"},{"key":"e_1_2_12_5_1","unstructured":"N. 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