{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:39:37Z","timestamp":1768923577223,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital long QT syndrome (LQTS) is rare but significant, as it carries a risk for ventricular arrhythmias and sudden cardiac death. Its diagnosis can be made clinically by serial ECGs, ambulatory ECG monitoring, and exercise stress testing; however, genetic testing is confirmatory in the majority of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we describe a rare case of phenotype\u2010positive LQTS in a 6\u2010year\u2010old heart transplant recipient, confirmed 5\u2009years after transplantation to be genotype\u2010positive and thus \u201cacquired\u201d from the transplanted heart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recognition of a persistently prolonged QTc interval on the recipient's serial ECGs led to ambulatory ECG monitoring and exercise stress testing\u2014both of which were suspicious for LQTS. Ultimately, genetic evaluation and cardiac biopsy were obtained and resulted positive for a <jats:italic>KCNQ1<\/jats:italic> pathogenic variant associated with Type 1 LQTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recognition of persistent, otherwise unexplained, ECG abnormalities can prompt genetic analysis of the allograft, leading to the potential life\u2010saving diagnosis of a channelopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.70075","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:23:26Z","timestamp":1743639806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acquired Genotype\u2010Positive Long <scp>QT<\/scp> Syndrome After Pediatric Heart Transplantation"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5136-3782","authenticated-orcid":false,"given":"Nicholas V.","family":"Barresi","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomic Medicine Children's Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-709X","authenticated-orcid":false,"given":"Brian","family":"Feingold","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"UpToDate","author":"Berul C. 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