{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T20:02:18Z","timestamp":1775332938470,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fontan patients undergoing heart transplant (HT) appear to require hemodialysis (HD) in the early post\u2010HT period at a rate that is higher than other patients, and often despite relatively preserved estimated renal function pre\u2010HT; but this has not been studied formally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Pediatric Heart Transplant Society (PHTS) database was used to identify all children \u2265\u20092\u2009years of age with Fontan circulatory failure (FCF) or cardiomyopathy (CM, benchmark lesion) who underwent isolated HT from 2005 to 2019. The primary endpoint was the need for postoperative dialysis, defined as any form of dialysis within the first 30\u2009days post\u2010HT. The secondary outcome was 30\u2010day all\u2010cause mortality. Pretransplant estimated glomerular filtration rate (eGFR) was calculated using the modified Schwartz formula. A subset of patients with available data also had renal function evaluated by a noncreatinine\u2010based method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1994 children who met the inclusion criteria, 13% had FCF and 87% had CM. While their ages were similar, FCF patients were 11% shorter and 9\u2009kg lighter than their CM counterparts. Prior to transplant, FCF patients had a lower serum creatinine and higher pretransplant eGFR by Schwartz formula compared to DCM patients. The Schwartz eGFR overestimated the measured GFR in a small subset of Fontan patients who had direct measurements. Overall, compared to CM patients, FCF patients had a 4.8\u2010fold higher incidence of any form of posttransplant dialysis (3.8% vs. 0.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Of the FCF patients who required posttransplant dialysis, the 30\u2010day post\u2010HT mortality was 40% vs. 14% in those who did not require dialysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.3). Multivariable analysis revealed that pre\u2010HT ECMO and longer CPB times were independently associated with posttransplant dialysis in patients with FCF; there was a trend toward association with higher pre\u2010HT eGFR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum creatinine pretransplant appears to be a poor predictor of renal replacement post\u2010HT in FCF patients and can grossly overestimate creatinine clearance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70090","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T02:38:46Z","timestamp":1746671926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Postoperative Dialysis in Fontan Patients Undergoing Heart Transplant: How Predictive is the Pretransplant Serum Creatinine?"],"prefix":"10.1111","volume":"29","author":[{"given":"Humera","family":"Ahmed","sequence":"first","affiliation":[{"name":"Division of Cardiology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dykes","sequence":"additional","affiliation":[{"name":"Division of Cardiology Lucile Packard Children's Hospital  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-7651","authenticated-orcid":false,"given":"Joshua","family":"Friedland\u2010Little","sequence":"additional","affiliation":[{"name":"Division of Cardiology Seattle Children's Hospital  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4327-1532","authenticated-orcid":false,"given":"Kevin P.","family":"Daly","sequence":"additional","affiliation":[{"name":"Division of Cardiology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6303-1264","authenticated-orcid":false,"given":"Kathleen","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-8085","authenticated-orcid":false,"given":"Marc E.","family":"Richmond","sequence":"additional","affiliation":[{"name":"Division of Cardiology Columbia University  New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-6815","authenticated-orcid":false,"given":"Simon","family":"Urschel","sequence":"additional","affiliation":[{"name":"Division of Cardiology Stollery Children's Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-736X","authenticated-orcid":false,"given":"Kurt","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Division of Cardiology C.S. Mott Children's Hospital  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Lucile Packard Children's Hospital  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7136-8337","authenticated-orcid":false,"given":"Christopher","family":"Almond","sequence":"additional","affiliation":[{"name":"Division of Cardiology Lucile Packard Children's Hospital  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Pediatric Heart Transplant Society","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.07.017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12617"},{"key":"e_1_2_10_4_1","unstructured":"R.Attieh M.Aljuhani H.Wadei et\u00a0al. \u201cRenal Failure and Mortality After Heart Alone Transplant in Recipients With eGFR <40 or on Dialysis in the United States \u201d Presented at: American Transplant Congress; June 3\u20137 2023 San Diego (Hybrid)."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.08.110"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.02.014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.58.2.259"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.04.018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12746"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.02.019"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135121990650"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.03.422"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.09.024"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.05.056"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.172"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210357"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04010907"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.70090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:34:05Z","timestamp":1764678845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.70090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/petr.70090"],"URL":"https:\/\/doi.org\/10.1111\/petr.70090","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,7]]},"assertion":[{"value":"2024-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70090"}}