{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:02Z","timestamp":1787016002988,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Expanded data regarding the safety and immunogenicity of live viral vaccines (LVV) during the posttransplant period has resulted in updated recommendations endorsing LVVs for select pediatric liver transplant (LT) recipients, a significant change from historical guidelines. The goal of this survey study was to understand current LVV practices among pediatric LT centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 20\u2010question email survey detailing center\u2010specific pre\u2010 and post\u2010LT LVV practices was distributed between May 1, 2024, and August 1, 2024, to a representative from each US center participating in the Society of Pediatric Liver Transplantation (SPLIT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall survey response rate was 95% (41\/43 centers). In the pretransplant period, 85% of centers (35\/41) administer LVVs starting at 6\u2009months of age, 7% (3\/41) wait until 9\u2009months, and another 7% start at 12\u2009months. The majority of centers (83%, 34\/41) require a 4\u2010week interval between LVVs and active transplant listing. In the posttransplant period, 39% of centers (16\/41) never recommend LVVs, citing perceived limited safety data (63%, 10\/16) and inability to reach provider consensus (31%, 5\/16) as reasons. Among the 25 centers that offer LVVs, barriers faced in implementing LVV protocols include parental concerns about change from historical recommendation (48%, 12\/25) and parental concerns about safety\/efficacy (36%, 9\/25).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The majority of pediatric LT centers across the US now recommend LVVs for select LT recipients. However, these centers face barriers in vaccinating all nonimmune eligible transplant recipients. Research is needed to understand and overcome barriers to widespread acceptance and implementation of evidence\u2010based LVV recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70100","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T03:40:31Z","timestamp":1746848431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Have Live Viral Vaccine Practices Among the Pediatric Liver Transplant Community Changed? A Survey Study of Pediatric Liver Transplant Centers Across the United States"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4021-5615","authenticated-orcid":false,"given":"Amy G.","family":"Feldman","sequence":"first","affiliation":[{"name":"Associate Professor of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition and the Digestive Health Institute, Children's Hospital Colorado University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda L.","family":"Beaty","sequence":"additional","affiliation":[{"name":"Adult and Child Center for Outcomes Research &amp; Delivery Science (ACCORDS) University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8470-4907","authenticated-orcid":false,"given":"Benhur Sirvan","family":"Cetin","sequence":"additional","affiliation":[{"name":"Associate Professor of Pediatric Infectious Diseases, Department of Pediatric Infectious Diseases Erciyes University, Faculty of Medicine  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-5221","authenticated-orcid":false,"given":"Lara","family":"Danziger\u2010Isakov","sequence":"additional","affiliation":[{"name":"Professor of Pediatrics, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center University of Cincinnati  Cincinnati Ohio 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