{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:38:09Z","timestamp":1764679089702,"version":"3.46.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autoimmune hemolytic anemia (AIHA) is a rare but significant complication following kidney transplantation, particularly in the context of immunosuppressive therapy. This report discusses a case of AIHA associated with tacrolimus in a pediatric patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 9\u2010year\u2010old boy who underwent living\u2010related kidney transplantation at age 6 for steroid\u2010resistant nephrotic syndrome developed BK virus nephropathy 2\u2009years posttransplant, which was managed with reduced tacrolimus and switched immunosuppressive therapy. Three years after the transplant, he presented with severe anemia and a positive direct Coombs test. Despite multiple blood transfusions and various treatments, his condition did not improve until tacrolimus was replaced with everolimus, resulting in rapid normalization of hemoglobin levels and resolution of hemolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tacrolimus\u2010associated AIHA is an uncommon complication among kidney transplant recipients, necessitating heightened awareness and timely intervention. Transitioning to alternative immunosuppressive therapies, such as everolimus or sirolimus, may prove effective in managing this condition. Although previous reports have described transitions from tacrolimus to sirolimus, this case marks the first documented instance of a switch to everolimus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.70104","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T10:02:50Z","timestamp":1747648970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autoimmune Hemolytic Anemia Following Kidney Transplant: The Role of Tacrolimus and Transition to Everolimus in a Pediatric Case"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3698-5609","authenticated-orcid":false,"given":"Mohamed S.","family":"Al Riyami","sequence":"first","affiliation":[{"name":"Pediatric Nephrology Unit, Department of Child Healthy Royal Hospital  Muscat Oman"},{"name":"Pediatric Residency Training Program Oman Medical Specialty Board  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badria","family":"Al Gaithi","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit, Department of Child Healthy Royal Hospital  Muscat Oman"},{"name":"Pediatric Residency Training Program Oman Medical Specialty Board  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Intisar","family":"Al Alawi","sequence":"additional","affiliation":[{"name":"National Genetic Center Ministry of Health  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anisa","family":"Al Maskari","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit, Department of Child Healthy Royal Hospital  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naifain","family":"Al Kalbani","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit, Department of Child Healthy Royal Hospital  Muscat Oman"},{"name":"Pediatric Residency 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